TWO DIMENSIONAL IR SPECTROSCOPY OF DESIGNED PENTAPEPTIDE

设计的五肽的二维红外光谱

• 批准号: 6480817
• 负责人: ROBIN Main HOCHSTRASSER
• 金额: $ 15.58万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480817
• 关键词: biological products; biomaterials; biomedical equipment development; biomedical resource; proteins; technology /technique

A form of two-dimensional (2D) vibrational spectroscopy was used to examine the structure of a cyclic penta-peptide (cyclo-Mamb-Abu-Arg-Gly-Asp) for which both the NMR and the x-ray structures are known. Spectrally resolved cross peaks occur in the off-diagonal region of the 2D IR spectrum, analogous to those of 2D NMR of proteins and peptides. The first results have been published (Proc. Natl. Acad. Sci. USA 96, 2036 (1999)).

使用了二维（2D）振动光谱的形式 检查环状五肽的结构 （Cyclo-mamb-abu-arg-gly-asp）NMR和X射线都 结构是已知的。 频谱分辨的横峰发生在 2D IR光谱的非对角区域，类似于2D 蛋白质和肽的NMR。 第一个结果已发布 （Proc。Natl。Acad。Sci。USA96，2036（1999））。