Population Genetics Theory

描述（由申请人提供）：理论人群的四个领域 遗传学将被研究。首先，我们将开发鲁棒估计器， DNA序列样本中最近的共同祖先的时间。的 目的是找到一个估计，以及当抽样人口 有任何人口结构或历史应用于Y染色体或 线粒体DNA，允许重组的修饰将被引入 和估计测试的常染色体和X连锁序列。该方法 旨在适用于大多数通常研究的DNA变体。第二 该项目研究了蛋白质-蛋白质相互作用与 使用已发表的数据库计算酵母的进化速率。我们将调查 蛋白质之间的相互作用是否对进化有直接影响 率或如果它是由适应性和进化之间的关系介导的 率在项目3中，我们研究了两种新的基因组印记模型。的 第一个是我们之前精确的人口遗传学的X链接版本 治疗第二种发展了三变量数量遗传 结构，其中一个变量是生长因子被一种 家长最后一个项目是致力于三个版本的演变， 复杂性第一个研究控制基因的等位基因的命运， 其他基因间的上位性相互作用水平。第二个扩展了我们的 生态位构建的理论工作， 由人类行为引起的非人类物种，例如使用抗生素， 是文化传播的。第三部分是研究联系的动力学 影响不同文化传播的基因之间的不平衡 性状，并应用于性选择。

DESCRIPTION (provided by applicant): Four areas of theoretical population genetics will be studied. In the first, we will develop robust estimators for the time to the most recent common ancestor in a sample of DNA sequences. The objective is to find an estimator that works well when the sampled population has any demographic structure or history. After application to Y-chromosomal or mitochondrial DNA, modifications to allow for recombination will be introduced and the estimator tested on autosomal and X-linked sequences. The method is designed to apply to most of the commonly studied DNA variants. The second project studies the relationship between protein-protein interactions and the rate of evolution in yeast using published databases. We will investigate whether the interaction between proteins has a direct effect on evolutionary rate or if it is mediated by the relationship between fitness and evolutionary rate. In Project 3, we investigate two new models of genomic imprinting. The first is an X-Iinked version of our previous exact population genetic treatment. The second develops a three-variable quantitative inheritance structure with one variable as the level of activation of growth factor by a parent. The final project is devoted to three versions of the evolution of complexity. The first studies the fate of alleles at a gene that controls the level of epistatic interaction between other genes. The second extends our theoretical work on niche construction to models for the genetic effects on non-human species caused by human behaviors, such as use of antibiotics, that are culturally transmitted. The third aims to study the dynamics of linkage disequilibrium between genes that affect different culturally transmitted traits, with an application to sexual selection.