Training Program in Host Pathogen Interactions

描述（由申请人提供）：拟建的培训项目将为博士后学员提供分子发病机制方面严格的实验室经验，强调宿主-病原体相互作用。培训将主要以实验室为基础，但也将包括由培训教员讲授的宿主-寄生虫相互作用的必修学期课程。对于医学博士学员（估计有一半），将在实验室实习之前进行实验室实习。最近的教师招聘工作已经导致在微生物发病机理的广泛领域形成了一个临界质量的已建立的研究人员，因此本申请建议建立一个综合培训计划的博士后学员在宿主-病原体相互作用。除了他们共同的研究兴趣外，这些教师中的许多人已经有了合作互动的证据。教师的研究兴趣包括毒力基因表达调控、宿主-病原体相互作用、分子免疫学和免疫防御、分子病毒学和生物信息学。该项目由12名教师组成，他们都获得了NIH的资助，作为一个群体，他们都有丰富的培训历史。作为一个整体，这个团队在各自的领域赢得了国内和国际的认可。培训教师代表了广泛的部门隶属关系，包括波士顿大学医学院医学系和微生物学系，以及波士顿大学生物医学工程系。该计划的主要目标将是：1)招募和招收最高质量的学员，包括代表性不足的少数民族；2)为这些受训者提供分子发病机理的多学科背景，并在一个重点项目中提供强化的实验室培训，以检查宿主-寄生虫相互作用；3)培养学员批判性思维，提出相关、可行的研究问题；4)培养学员的道德行为意识；5)帮助学员培养有效的书面和口头沟通技巧；6)促进宿主-病原体相互作用训练计划的学生和教师之间的协作互动。

DESCRIPTION (provided by applicant): The proposed training program will provide postdoctoral trainees with a rigorous laboratory experience in molecular pathogenesis, emphasizing host-pathogen interactions. Training will be primarily laboratory based, but will also include a required semester course in host-parasite interactions taught by the training faculty. For MD trainees (estimated to be half) a laboratory practicum will precede their assignment to laboratories. Recent faculty recruitment efforts have resulted in the formation of a critical mass of established investigators in the broad area of microbial pathogenesis and accordingly this application proposes to establish an integrated training program for post doctoral trainees in host-pathogen interactions. In addition to their common research interests, many of these faculty already have evidence of collaborative interactions. Faculty research interests encompass areas that include regulation of virulence gene expression, host- pathogen interactions, molecular immunology and immune defense, molecular virology and bioinformatics. The program consists of 12 faculty, all of whom hold NIH grants and who, as a group, have had a substantial training history. As a whole, this group has earned national and international recognition in their respective fields. The training faculty represents a broad range of departmental affiliations, including the Departments of Medicine and Microbiology at Boston University School of Medicine, and the Division of Biomedical Engineering at Boston University. The major goal of the program will be to: 1) recruit and enroll trainees of the highest quality including underrepresented minorities; 2) provide these trainees with a multidisciplinary background in molecular pathogenesis coupled with intensive laboratory training in a focused project that examines a host-parasite interaction(s); 3) to teach trainees to think critically and to ask relevant and feasible research questions; 4) to instill these trainees with a sense of ethical behavior; 5) to help develop effective written and oral communication skills among the trainees; and 6) to facilitate collaborative interactions among both students and faculty of the host-pathogen interaction training Program.