Training Program in Infectious Diseases in the Immunocompromised Host

免疫功能低下宿主传染病培训计划

• 批准号: 10450829
• 负责人: MICHAEL J BOECKH
• 金额: $ 50.56万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450829
• 关键词: Communicable Diseases; Immunocompromised Host; Training Programs

PROJECT SUMMARY Our interdisciplinary training program, based at the Fred Hutchinson Cancer Research Center (Fred Hutch), focuses on Infectious Diseases in the Immunocompromised Host. Our objective is to recruit and train outstanding physician-scientists and postdoctoral PhD scientists to perform basic, translational and clinical research, using state-of-the-art methods and analytical techniques. Our overarching goal is to train the next generation of leaders in the field, who will use their expertise to advance our understanding of infectious disease biology and pathogenesis, and to develop novel strategies to prevent, treat and control infectious diseases in high-risk immunocompromised patients. There is increasing demand for research training in this field: infection remains a major cause of morbidity and mortality for immunocompromised hosts, and millions are at risk or affected by established pathogens and emerging pathogens such as SARS-CoV-2. The population of immunocompromised individuals in the United States continues to grow, driven by advances in transplantation techniques and cancer treatments, increased survival of these patients, and the development of novel drugs and biological agents to treat autoimmune diseases. As part of an NCI-designated cancer consortium whose renowned faculty have contributed landmark advances in the field of infectious diseases of the immunocompromised host for the past 40 years, and whose expertise collectively encompass all facets of this field, Fred Hutch is uniquely positioned to successfully lead this training program. In partnership with the University of Washington (UW), the Infectious Disease Sciences Program of Fred Hutch has an excellent, multi-decade track record of training physician-scientists and postdoctoral PhD scientists who launch independent research careers in academia, government research, or industry leadership positions. Our funded T32 grant has allowed us to expand our training program and solidify funding for trainees in this specialized area of infectious diseases. We seek to maintain this high standard of training; the T32 will support 2 new, qualified trainees (MDs and/or PhDs) per year, for 3 years of training each. T32 trainees pursue one of three consolidated research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Clinical Research, Infection Prevention, and Stewardship; 2) Immunology/Immunogenetics; and 3) Microbiome and Pathogenesis. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees participate in a rigorous core curriculum consisting of courses, lectures, retreats, research and targeted career development activities; trainees also have the opportunity to complete a master’s degree at UW. Our training program helps to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and provides those trainees with the skills and expertise to successfully transition into independent research careers.

项目总结 我们的跨学科培训计划，以弗雷德·哈钦森癌症研究中心(弗雷德·哈奇)为基础， 重点放在免疫受损宿主中的传染病。我们的目标是招募和培训 杰出的内科科学家和博士后科学家，从事基础、翻译和临床工作 研究，使用最先进的方法和分析技术。我们的首要目标是培养下一代 一代该领域的领导者，他们将利用他们的专业知识来推动我们对传染性疾病的理解 疾病生物学和发病机制，并开发预防、治疗和控制传染病的新策略 高危免疫受损患者的疾病。对这方面的研究培训的需求越来越大 领域：感染仍然是免疫受损宿主和数百万人发病和死亡的主要原因 面临风险或受到已有病原体和新出现的病原体的影响，如SARS-CoV-2。这个 在免疫缺陷个体的数量继续增长的推动下，在美国 移植技术和癌症治疗，提高这些患者的存活率，以及发展 治疗自身免疫性疾病的新型药物和生物制剂。作为NCI指定的癌症的一部分 其著名教员在传染病领域取得了里程碑式的进展 在过去的40年里，免疫受损的宿主，其专业知识共同涵盖了 在这一领域，弗雷德·哈奇是成功领导这一培训计划的独特人选。与 华盛顿大学(UW)，弗雷德·哈奇的传染病科学项目有一个很好的， 几十年来培养内科科学家和博士后科学家的记录 在学术界、政府研究或行业领导岗位上从事独立研究工作。我们的资金来源 T32助学金使我们扩大了培训计划，并巩固了对该专业学员的资助 传染病疫区。我们寻求保持这一高标准的培训；T32将支持2个新的， 每年合格的受训人员(医学博士和/或博士)，每人接受3年的培训。T32学员攻读以下三种课程之一 综合研究跟踪，代表我们免疫受损宿主计划的独特优势 及其导师：1)临床研究、感染预防和管理；2)免疫学/免疫遗传学； (3)微生物组与发病机制。这些培训课程提供了该领域的独特方面的培训，并将 确保学员具备流行病学、诊断、管理和宿主病原体方面的专门知识 互动。所有受训人员都参加了严格的核心课程，包括课程、讲座、务虚会、 研究和有针对性的职业发展活动；受训人员还有机会完成硕士学位 威斯康星大学学位。我们的培训计划有助于满足国家对专注于临床研究的研究人员的需求 和/或免疫受损宿主中传染病的实验室调查，并提供 具有成功过渡到独立研究职业的技能和专业知识的受训者。