Training Program in Infectious Diseases in the Immunocompromised Host

免疫功能低下宿主传染病培训计划

• 批准号: 10666955
• 负责人: MICHAEL J BOECKH
• 金额: $ 27万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10666955
• 关键词: Communicable Diseases; Immunocompromised Host; Training Programs

PROJECT SUMMARY Our interdisciplinary training program, based at the Fred Hutchinson Cancer Research Center (Fred Hutch), focuses on Infectious Diseases in the Immunocompromised Host. Our objective is to recruit and train outstanding physician-scientists and postdoctoral PhD scientists to perform basic, translational and clinical research, using state-of-the-art methods and analytical techniques. Our overarching goal is to train the next generation of leaders in the field, who will use their expertise to advance our understanding of infectious disease biology and pathogenesis, and to develop novel strategies to prevent, treat and control infectious diseases in high-risk immunocompromised patients. There is increasing demand for research training in this field: infection remains a major cause of morbidity and mortality for immunocompromised hosts, and millions are at risk or affected by established pathogens and emerging pathogens such as SARS-CoV-2. The population of immunocompromised individuals in the United States continues to grow, driven by advances in transplantation techniques and cancer treatments, increased survival of these patients, and the development of novel drugs and biological agents to treat autoimmune diseases. As part of an NCI-designated cancer consortium whose renowned faculty have contributed landmark advances in the field of infectious diseases of the immunocompromised host for the past 40 years, and whose expertise collectively encompass all facets of this field, Fred Hutch is uniquely positioned to successfully lead this training program. In partnership with the University of Washington (UW), the Infectious Disease Sciences Program of Fred Hutch has an excellent, multi-decade track record of training physician-scientists and postdoctoral PhD scientists who launch independent research careers in academia, government research, or industry leadership positions. Our funded T32 grant has allowed us to expand our training program and solidify funding for trainees in this specialized area of infectious diseases. We seek to maintain this high standard of training; the T32 will support 2 new, qualified trainees (MDs and/or PhDs) per year, for 3 years of training each. T32 trainees pursue one of three consolidated research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Clinical Research, Infection Prevention, and Stewardship; 2) Immunology/Immunogenetics; and 3) Microbiome and Pathogenesis. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees participate in a rigorous core curriculum consisting of courses, lectures, retreats, research and targeted career development activities; trainees also have the opportunity to complete a master’s degree at UW. Our training program helps to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and provides those trainees with the skills and expertise to successfully transition into independent research careers.

项目概要 我们的跨学科培训计划位于 Fred Hutchinson 癌症研究中心 (Fred Hutch)， 专注于免疫功能低下宿主的传染病。我们的目标是招募和培训 杰出的医师科学家和博士后博士科学家进行基础、转化和临床研究 使用最先进的方法和分析技术进行研究。我们的首要目标是培养下一个 该领域的一代领导者，他们将利用他们的专业知识来增进我们对传染病的理解 疾病生物学和发病机制，并制定预防、治疗和控制传染病的新策略 高危免疫功能低下患者的疾病。这方面的研究培训需求不断增加 领域：感染仍然是免疫功能低下宿主和数百万人发病和死亡的主要原因 面临已确定的病原体和新出现的病原体（例如 SARS-CoV-2）的风险或影响。这 在技​​术进步的推动下，美国免疫功能低下人群的数量持续增长 移植技术和癌症治疗，提高这些患者的生存率，以及开发 治疗自身免疫性疾病的新药和生物制剂。作为 NCI 指定癌症的一部分 其著名教师在传染病领域做出了里程碑式的进展 过去 40 年来一直是免疫功能低下的宿主，其专业知识涵盖了免疫系统的各个方面 在这一领域，Fred Hutch 具有独特的优势，能够成功领导该培训计划。与合作伙伴 华盛顿大学 (UW) 的 Fred Hutch 传染病科学项目拥有出色的、 数十年来培训医师科学家和博士后科学家的记录 学术界、政府研究或行业领导职位的独立研究职业。我们资助的 T32 赠款使我们能够扩大我们的培训计划并巩固对该专业学员的资助 传染病领域。我们力求保持这种高标准的培训； T32 将支持 2 个新的、 每年合格的实习生（医学博士和/或博士），每人接受 3 年的培训。 T32学员追求三者之一 综合研究轨迹代表了我们免疫功能低下宿主计划的独特优势 及其导师：1) 临床研究、感染预防和管理； 2）免疫学/免疫遗传学； 3) 微生物组和发病机制。这些课程提供该领域独特方面的培训，并将 确保学员发展流行病学、诊断、管理和宿主病原体方面的专业知识 互动。所有学员都参加严格的核心课程，包括课程、讲座、静修、 研究和有针对性的职业发展活动；学员还有机会完成硕士学位 威斯康星大学学位。我们的培训计划有助于满足国家对专注于临床的研究人员的需求 和/或对免疫受损宿主的传染病进行实验室调查，并提供这些 具有成功过渡到独立研究职业的技能和专业知识的学员。