Training Program in Infectious Diseases in the Immunocompromised Host

项目摘要 我们寻求在弗雷德哈钦森癌症研究中心建立一个跨学科的培训计划 (Fred Hutch）专注于免疫受损宿主的传染病。该计划的目的是 培养医生科学家和博士后博士科学家进行基础，翻译和临床 研究高危地区传染病的生物学、发病机理、诊断、治疗和预防 免疫功能低下的患者。治疗自身免疫性疾病的新药和生物制剂的研究进展 移植技术和癌症治疗以及这些患者存活率的提高 在美国，免疫抑制患者的数量显著增加。感染 仍然是免疫功能低下宿主发病和死亡的主要原因，数百万人面临风险或 由于受到新出现的和已确定的病原体的影响，对这一领域的研究培训的需求日益增加。 弗雷德·哈奇的传染病科学项目与华盛顿大学合作 培训50名传染病研究员和博士后科学家在实验室或转化研究， 在过去的25年里，免疫功能低下的宿主中的传染病领域。我们拥有一支优秀 在培训结束后，学员过渡到完全职业独立的跟踪记录， 超过80%的学员现在在学术界，政府研究或行业领导职位上工作。 显然需要扩大我们的培训计划，并巩固这一专业的受训人员的资金。 传染病领域。我们正在申请资助两名合格的受训人员（医学博士和/或博士） 每年为每名受训人员提供两年的培训。这笔资金将用于4个国家之一的培训。 代表我们的免疫功能低下的主机程序及其导师的独特优势的研究轨道： 1)流行病学，病原体动力学和临床试验; 2）免疫学/免疫遗传学; 3）微生物组学和 发病机制;和4）感染预防和医院流行病学。这些赛道提供独特的训练 这一领域的各个方面，并将确保受训人员发展流行病学，诊断，管理 和宿主-病原体相互作用。所有受训人员都将参加严格的核心课程， 讲座，务虚会，研究和有针对性的职业发展活动;学员也有机会， 在华盛顿大学完成公共卫生硕士学位。拟议的培训计划 将有助于满足国家对研究人员的需求，这些研究人员将其临床和/或实验室研究集中在 免疫功能低下宿主的传染病，并将为这些学员提供技能和 专业知识，以成功地过渡到独立的研究事业。

PROJECT SUMMARY We seek to establish an interdisciplinary training program at the Fred Hutchinson Cancer Research Center (Fred Hutch) focused on Infectious Diseases in the Immunocompromised Host. The purpose of the program is to train physician-scientists and post-doctoral PhD scientists to perform basic, translational and clinical research in the biology, pathogenesis, diagnosis, treatment and prevention of infectious diseases in high-risk immunocompromised patients. Novel drugs and biological agents to treat autoimmune diseases, advances in transplantation techniques and cancer treatments as well as increased survival of these patients have resulted in a significant growth in the population of patients with immunosuppression in the United States. Infection remains a major cause of morbidity and mortality for immunocompromised hosts, and with millions at risk or affected by emerging and established pathogens, there is increasing demand for research training in this field. The Infectious Disease Sciences Program of the Fred Hutch has partnered with the University of Washington in training 50 Infectious Disease fellows and postdoctoral scientists in laboratory or translational research in the area of Infectious Diseases in the immunocompromised host over the last 25 years. We have an excellent track record of transitioning trainees to full career independence at the conclusion of their training with more than 80% of our trainees now working in academia, government research or industry leadership positions. There is a clear need to both expand our training program and solidify funding for trainees in this specialized area of Infectious Diseases. We are requesting funding to support two qualified trainees (MDs and/or PhDs) per year, for two years of training for each of the trainees. This funding will be utilized for training in one of 4 research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Epidemiology, Pathogen Dynamics, and Clinical Trials; 2) Immunology/Immunogenetics; 3) Microbiome and Pathogenesis; and 4) Infection Prevention and Hospital Epidemiology. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees will participate in a rigorous core curriculum consisting of courses, lectures, retreats, research, and targeted career development activities; trainees also have the opportunity to complete a Masters in Public Health degree at the University of Washington. The proposed training program will help to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and will provide those trainees with the skills and expertise to successfully transition into independent research careers.