Training Program in Infectious Diseases in the Immunocompromised Host

项目总结 我们寻求在弗雷德·哈钦森癌症研究中心建立一个跨学科的培训计划 (弗雷德·哈奇)专注于免疫受损宿主中的传染病。该计划的目的是 培养内科科学家和博士后科学家从事基础、翻译和临床工作 高危传染病的生物学、发病机制、诊断、治疗和预防研究 免疫功能受损的病人。治疗自身免疫性疾病的新型药物和生物制剂进展 移植技术和癌症治疗以及这些患者存活率的提高导致了 在美国，免疫抑制患者的人数显著增加。感染 仍然是免疫受损宿主发病和死亡的主要原因，数百万人面临风险或 受新出现和已有病原体的影响，对这一领域的研究培训的需求越来越大。 弗雷德·哈奇的传染病科学项目已与华盛顿大学合作 培训50名传染病研究员和博士后科学家从事实验室或翻译研究 过去25年免疫受损宿主中的传染病病区。我们有一个很棒的 培训结束后过渡到完全职业独立的实习生的跟踪记录 我们80%以上的受训人员目前在学术界、政府研究或行业领导职位工作。 显然有必要扩大我们的培训计划，并巩固对该专业受训人员的资助 传染病病区。我们正在申请资金支持两名合格的实习生(医学博士和/或博士) 每年，为每个受训人员提供两年的培训。这笔资金将用于以下4个项目之一的培训 代表我们免疫受损宿主计划及其导师的独特优势的研究跟踪： 1)流行病学、病原体动力学和临床试验；2)免疫学/免疫遗传学；3)微生物组和 发病机制；4)感染预防和医院流行病学。这些路径提供独特的培训 并将确保受训人员发展流行病学、诊断、管理方面的专门知识 以及宿主与病原体的相互作用。所有受训人员将参加由课程组成的严格的核心课程， 讲座、务虚会、研究和有针对性的职业发展活动；实习生还有机会 在华盛顿大学攻读公共卫生硕士学位。拟议的培训计划 将有助于满足国家对研究人员的需求，这些研究人员将他们的临床和/或实验室调查集中在 免疫受损宿主中的传染病，并将为这些受训人员提供技能和 成功过渡到独立研究职业的专业知识。

PROJECT SUMMARY We seek to establish an interdisciplinary training program at the Fred Hutchinson Cancer Research Center (Fred Hutch) focused on Infectious Diseases in the Immunocompromised Host. The purpose of the program is to train physician-scientists and post-doctoral PhD scientists to perform basic, translational and clinical research in the biology, pathogenesis, diagnosis, treatment and prevention of infectious diseases in high-risk immunocompromised patients. Novel drugs and biological agents to treat autoimmune diseases, advances in transplantation techniques and cancer treatments as well as increased survival of these patients have resulted in a significant growth in the population of patients with immunosuppression in the United States. Infection remains a major cause of morbidity and mortality for immunocompromised hosts, and with millions at risk or affected by emerging and established pathogens, there is increasing demand for research training in this field. The Infectious Disease Sciences Program of the Fred Hutch has partnered with the University of Washington in training 50 Infectious Disease fellows and postdoctoral scientists in laboratory or translational research in the area of Infectious Diseases in the immunocompromised host over the last 25 years. We have an excellent track record of transitioning trainees to full career independence at the conclusion of their training with more than 80% of our trainees now working in academia, government research or industry leadership positions. There is a clear need to both expand our training program and solidify funding for trainees in this specialized area of Infectious Diseases. We are requesting funding to support two qualified trainees (MDs and/or PhDs) per year, for two years of training for each of the trainees. This funding will be utilized for training in one of 4 research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Epidemiology, Pathogen Dynamics, and Clinical Trials; 2) Immunology/Immunogenetics; 3) Microbiome and Pathogenesis; and 4) Infection Prevention and Hospital Epidemiology. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees will participate in a rigorous core curriculum consisting of courses, lectures, retreats, research, and targeted career development activities; trainees also have the opportunity to complete a Masters in Public Health degree at the University of Washington. The proposed training program will help to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and will provide those trainees with the skills and expertise to successfully transition into independent research careers.