500 MHz Wide Bore NMR System

描述（由申请人提供）：此申请要求500美元的资金 MHz宽口径自屏蔽核磁共振（NMR）系统 Memorial Sloan Kettering Cancer Center（MSKCC）MSKCC目前有一个NMR 适用于细胞和体内研究的仪器，4.7T Omega系统（33 cm 1988年购买。这块磁铁的控制台正在升级 但它的磁场强度已经消失了最先进的技术”， 得到了外部审查小组和几个赠款评论的认可。在过去 1.5多年来，MSKCC的成像相关资金大幅增加 包括小动物成像补助金，细胞和分子成像 中心，和生物工程财团赠款，除了多个 劳尔·赠款。根据最近调查人员和资助项目的增加， 还需要更多的NMR研究设备。我们选择了这个 仪器，因为它提供了最高的磁场在严重 空间和金钱的限制，它补充了4.7T系统，并在 与升级后的4.7T系统相结合，将为几乎所有的 MSKCC对成像和代谢研究感兴趣的研究人员的需求。 该项目将支持16名研究人员提供的22笔赠款。那里 是六个主要用户和第七个主要“组”（鼠标成像，以确定 肿瘤形成的基因多态性-5名参与者）。主要用户群体 包括药理学，细胞生物学，医学物理学，神经学，和 放射学.这22项赠款还包括外科手术的申请， 医学和放射肿瘤学。这些科学家中的大多数都表明 大多数项目都有初步数据，这表明需要核磁共振支持。 其中两名调查人员来自纽约医院，一家相邻的（独立的） 机构。如果得到资助，这项建议的一个优点是，它支持 细胞和体内成像研究领域，包括五个主要 医疗/研究机构，除了一个主要的动物医疗中心。 其中三个机构共享一个共同的动物服务， 来自多个机构的动物可以进行研究，而不必担心 交叉感染因此，该应用将对外界有一定的借鉴意义 机构，除了在MSKCC的研究人员的广泛基础。应注意 在过去，我们与4个外部机构中的3个合作， 两个外部项目注意到（有支持性的初步数据），并打算 继续这样做。因此，这项建议，如果得到资助，将支持一个非常广泛的 科学家和医学研究人员在这一领域的基础。

DESCRIPTION (provided by applicant): This application requests funds for a 500 MHz wide bore, self shielded, nuclear magnetic resonance (NMR) system for Memorial Sloan Kettering Cancer Center (MSKCC). MSKCC currently has one NMR instrument suitable for cellular and in vivo studies, a 4.7T Omega system (33cm bore magnet), purchased in 1988. The console of this magnet is being upgraded but its field strength is no longer ?state of the art" and this has been recognized by an outside review panel and several grant critiques. In the last 1.5 years there has been a major increase in imaging related funding at MSKCC including a Small Animal Imaging Grant, A Cellular and Molecular Imaging Center, and a Biological Engineering Consortium Grant, in addition to multiple R0l grants. Based on recent increases in investigators and funded projects, there is also a need for more NMR research equipment. We have selected this instrument since it provides the highest magnetic field available within severe constraints of space and money, it complements the 4.7T system, and in combination with the upgraded 4.7T system, will serve virtually all of the needs of investigators at MSKCC interested in imaging and metabolic research. There are 22 grants from 16 investigators that this program will support. There are six major users and a seventh major "group" (mouse imaging to determine gene penetrance for tumor formation - 5 participants). The major user group encompasses Pharmacology, Cell Biology, Medical Physics, Neurology, and Radiology. The 22 supported grants also include applications from Surgery, Medicine, and Radiation Oncology. Most of these scientists have shown a need for NMR support as shown by the fact that most projects have preliminary data. Two of the investigators are from New York Hospital, an adjacent (independent) institution. A strength of this proposal if it is funded, is that it supports cellular and in vivo imaging research in an area that encompasses five major medical/research institutions, in addition to a major animal medical center. Three of these institutions share a common animal service, and therefore animals from multiple institutions can be studied without fear of cross-infection. Thus this application will have some benefit to outside institutions, in addition to a broad base of researchers at MSKCC. It is noted that in the past we have collaborated with 3 of the 4 outside institutions, as noted by two outside projects (with supportive preliminary data), and intend to continue to do this. Thus this proposal, if funded , will support a very broad base of scientist and medical researchers in this area.