ANIMAL IMAGING

动物成像

• 批准号: 7671810
• 负责人: JASON Arthur KOUTCHER
• 金额: $ 13.64万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7671810
• 关键词: Animals; Area; Arts; Autoradiography; Bioluminescence; Capital; Detection; Development; Disease; Disease regression; Disseminated Malignant Neoplasm; Effector Cell; Equipment; Evaluation; Film; Floor; Fluorescence; Fluorescent Probes; Gene Expression; Genetic; Housing; Human; Hypoxia; Image; Imaging Techniques; Immune; Improve Access; Incidence; Intervention; Invasive; Knock-out; Laboratory Research; Localized; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Memorial Sloan-Kettering Cancer Center; Metabolic; Microtome - medical device; Modality; Modeling; Modernization; Monitor; Numbers; Optical Tomography; Optics; Patients; Pharmacodynamics; Phase; Photons; Positron; Process; Radioisotopes; Radiolabeled; Reporter Genes; Research; Research Infrastructure; Research Personnel; Resolution; Rodent; Rodent Model; Screening procedure; Services; Spectrum Analysis; Staging; Stem cells; System; Testing; Tracer; Transgenic Organisms; Tumor Biology; Ultrasonography; Validation; X-Ray Computed Tomography; Xenograft Model; base; biosecurity; cancer cell; digital; disease natural history; fluorescence microscope; host neoplasm interaction; in vivo; insight; instrumentation; molecular imaging; neoplastic cell; optical imaging; radiotracer; single photon emission computed tomography; spectroscopic imaging; tomography; trafficking; tumor; tumor initiation

The Animal Imaging Core provides services for molecular imaging of rodent models of human cancer. The Core provides investigators with non-invasive, high-resolution quantitative imaging-based capabilities for metabolic and genetic characterization of tumors and their microenvironment, including in vivo trafficking of tumor cells. This is accomplished by monitoring of "directly-targeting" probes and of the expression of single and multi-modality reporter genes using optical (bioluminescence and fluorescence), radionuclide (PET, SPECT, and autoradiography), MRI/MRS, CT, and US imaging. These imaging techniques are wellestablished at MSKCC for small-animal imaging studies. They are quantitative and non-invasive and thus readily adaptable to longitudinal studies. The Animal Imaging Core also provides investigators with access to critical ancillary equipment and services such as a Fuji Film BAS-180011 phosphor-plate digital autoradiography system, a digital-camera-equipped Olympus B 201 fluorescence microscope with motorized stage, and a Microm HM500M cryostatic microtome. As part of a major expansion and modernization of MSKCC's infrastructure (Phase 1), part of the Imaging Core has recently re-located to the C4 level within the Vivarium of the new Zuckerman Research Center. This area provides enhanced biosecurity and functionality and houses our R4 and Focus 120 microPET dedicated high-resolution small-animal (rodent) PETs, new MS 200 optical imaging system, microCAT II dedicated small-animal (rodent) CT, and X-SPECT dedicated small-animal SPECT-CT. The existing MS 100 optical imaging system and recently installed Vevo 770 ultrasound system have been re-located to refurbished space on the 12th floor of the Rockefeller Research Laboratory providing improved access to the primary users of these two systems. The Imaging Core's 4.7-T 40-cm bore and 7.0-T 31-cm Brucker NMR imaging and spectroscopy systems are currently located in the MRI Building. In Phase 2 of MSKCC's capital expansion and modernization, all of the foregoing instrumentation of the Imaging Core will be consolidated in spacious, state-of the-art quarters with the Center's vivarium.

Animal Imaging Core为人类癌症的啮齿动物模型提供分子成像服务。 Core为研究者提供了基于非侵入性、高分辨率定量成像的功能 用于肿瘤及其微环境的代谢和遗传表征，包括体内运输 肿瘤细胞。这是通过监测“直接靶向”探针和“靶向”探针的表达来实现的。 使用光学（生物发光和荧光）、放射性核素 (PET SPECT和放射自显影）、MRI/MRS、CT和US成像。这些成像技术已经很成熟了 用于小动物成像研究。它们是定量的和非侵入性的，因此 易于适应纵向研究。动物成像核心还为研究人员提供了访问 关键的辅助设备和服务，如富士胶片BAS-180011荧光板数字 放射自显影系统，配备数码相机的Olympus B 201荧光显微镜， 电动载物台和Microm HM 500 M低温恒温切片机。 作为MSKCC基础设施（第1阶段）重大扩建和现代化的一部分， 核心最近已重新定位到C4水平内的动物园的新朱克曼研究中心。 该区域提供增强的生物安全性和功能，并容纳我们的R4和Focus 120 microPET 专用高分辨率小动物（啮齿动物）PET、新型MS 200光学成像系统、microCAT II 专用小动物（啮齿动物）CT和X-SPECT专用小动物SPECT-CT。现有MS 100个光学成像系统和最近安装的Vevo 770超声波系统已被重新安置， 洛克菲勒研究实验室12楼的翻新空间， 这两个系统的主要用户。Imaging Core的4.7-T 40 cm孔径和7.0-T 31 cm Brucker 核磁共振成像和光谱系统目前位于核磁共振大楼。在MSKCC的第二阶段， 资本扩张和现代化，所有上述仪器的成像核心将是 在中心的动物园里，在宽敞的、最先进的宿舍里巩固。