动物成像核心-猫眼课题宝

动物成像核心

批准号：

8555204

负责人：

JASON Arthur KOUTCHER

金额：

$20.31万

依托单位：

SLOAN-KETTERING INST CAN RESEARCH

依托单位国家：

美国

项目类别：

财政年份：

2001

资助国家：

美国

项目状态：

已结题

起止时间：

2001-09-14 至 2016-08-31

来源：

https://reporter.nih.gov/project-details/8555204

关键词：

Adenocarcinoma Anatomy Androgen Receptor Animals Antibodies Area Biochemistry Biological Assay Biological Markers Biomedical Engineering Cancer Biology Choline Clinic Clinical Detection Development Disease Emission-Computed Tomography Environment Genetic Goals Heart Human Idoxuridine Image Imaging Techniques Immunologics Interruption Intervention Investigation Kinetics Knock-out Laboratories Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Malignant neoplasm of prostate Medicine Metabolic Marker Methionine Methodology Methods Modality Modeling Monitor Mus Natural History Neoplasm Metastasis Optics PTEN gene Pathway interactions Photons Physiologic pulse Physiology Pilot Projects Positron-Emission Tomography Pre-Clinical Model Process Program Development Prostate Prostatic Neoplasms Radiochemistry Radioimmunoconjugate Radioisotopes Radionuclide Imaging Research Research Personnel Resolution Resources Rodent Model Small Animal Imaging Resource Programs Specificity TMPRSS2 gene Temperature Testing Tracer Transgenic Model Transgenic Organisms Translational Research Translations Tumor Markers United States National Institutes of Health Validation X-Ray Computed Tomography bioimaging chemotherapy cohort disease natural history fluorodeoxyglucose human disease image registration imaging modality inhibitor/antagonist mouse model neoplastic novel optical imaging pre-clinical programs radiofrequency respiratory response tumor tumor growth

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中文摘要

翻译

动物成像核心（核心E）的目的是支持翻译的研究目标， SPORE通过（1）为前列腺肿瘤模型的研究提供成像支持，以及（2）研究临床前模型，用于开发、测试和验证新的治疗方法，包括遗传和化疗，提高前列腺癌的治疗效果。动物成像中心负责以下工作： - 支持最先进的MR、PET和光学成像设备，以实现最佳的小动物成像研究 - 开发优化MR和PET研究的技术方法 - 提供磁共振波谱（MRS）、光学和放射性核素成像，以支持临床前发展研究计划（DRP）中的试点研究 - 成像生物标志物的开发和验证

英文摘要

The purpose of the Animal Imaging Core (Core E) is to support the translational research objectives of the SPORE by (1) providing imaging support for studies of prostate tumor models, and (2) investigating preclinical models for developing, testing, and validating new treatments, both genetic and chemotherapy, to enhance treatment of prostate cancer. The Animal Imaging Core is responsible for the following: - Support state-of-the-art MR, PET, and optical imaging facilities for optimal small-animal imaging studies - Develop technical methods to optimize MR and PET studies - Provide magnetic resonance spectroscopy (MRS), optical and radionuclide imaging to support preclinical pilot studies in the Developmental Research Program (DRP) - Development and validation of imaging biomarkers

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