ANIMAL IMAGING CORE

影像学研究为非侵入性检测前列腺中重要的关键分子提供了可能性 癌症生物学和医学。小动物成像核心的目标是提供成像研究 支持参与定义前列腺癌特征的研究人员，通常在分子水平上， 水平影像学研究可作为一个非侵入性的分子变化的表型相关。的 小动物成像中心的主要职责是提供正电子发射断层扫描 (PET)、单光子发射计算机断层扫描（SPECT）、光学和磁共振成像 和光谱能力在最高的空间分辨率可能监测分子的影响， 变化和用于动物模型中的癌症生物学研究。可用的仪器包括2个磁性 共振成像/光谱系统（4.7T/40 cm孔径和7.0T/31 cm孔径系统），2 MIcroPET 系统、MicroCT、MicroSPECT和光学成像设备（IVIS）， 生物发光成像小动物成像核心在上一个周期的成就包括 基于SPORE资助的研究，14篇出版物和2项赠款与小动物成像直接相关。 根据我们以前的经验，进行的成像研究的很大一部分将集中在 获得高分辨率解剖成像。这些研究的目标将是检测肿瘤在最低限度 负荷，表征生长速率，并监测对新疗法的反应。其中一些研究（RP 4） 可以利用新的成像方案，例如将3 '-脱氧-3'-（18）F-氟胸苷（FLT）成像为 增殖标记物、增殖的MR光谱测量（并将PET和MR数据相关联 与其他和Ki 67测量），和动态对比增强MRI，以评估抗血管生成 剂.此外，我们将评估不同的PET放射性核素示踪剂作为潜在的成像 包括11 C-甲硫氨酸、18F-氟脱氧葡萄糖、18F-氟二氢睾酮和1241- 碘脱氧尿苷），这将与病理学数据相关。重点将是确保 成像研究期间的生理适当环境（温度控制、心脏和呼吸 率）。设计用于同时对多只小鼠进行成像的射频谐振器的构建， 将进行吸入麻醉、体温监测等。为了提高空间分辨率， 将研究灵敏的谐振器线圈。作为核心设施，主要目标将是提供 先进的成像能力，改善图像处理和分析，以提高多模态的准确性 成像（与其他赠款合作支持），以及适当的放射性示踪剂， 由纪念斯隆凯特琳癌症中心的回旋加速器和放射化学中心提供

Imaging studies offer the potential for non-invasive detection of key molecules that are important in prostate cancer biology and medicine. The goal of the Small Animal Imaging Core is to provide imaging research support to investigators who are involved in defining a prostate cancer signature, often at the molecular level. Imaging studies may serve as a non-invasive phenotypic correlate of the molecular changes. The primary responsibility of the Small Animal Imaging Core will be to provide positron emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), optical, and magnetic resonance imaging and spectroscopy capability at the highest spatial resolution possible to monitor the effect of molecular changes and for the study of cancer biology in animal models. Available instrumentation include 2 magnetic resonance imaging/spectroscopy systems (4.7T/40 cm bore and 7.0T/31 cm bore systems), 2 MIcroPET systems, MicroCT, MicroSPECT, and optical imaging equipment (IVIS) for fluorescence and bioluminescence imaging. Achievements of the Small Animal Imaging Core during the last interval include 14 publications and 2 grants directly related to small animal imaging based on SPORE funded research. Based on our previous experience, a significant portion of the imaging research performed will focus on obtaining high resolution anatomic imaging. The goals of these studies will be to detect tumor at minimal burden, characterize growth rates, and monitor response to novel therapies. Some of these studies (RP4) may utilize novel imaging schemes such as imaging 3'-deoxy-3'-(18)F-fluorothymidine (FLT) as a proliferation marker, MR spectroscopic measurements of proliferation (and correlate the PET and MR data with each other and Ki67 measurements), and dynamic contrast enhanced MRI to evaluate antiangiogenesis agents. In addition, we will evaluate different PET radionuclide tracers as potential imaging agents including 11C-methionine, 18F-fluorodeoxyglucose, 18F-fluorodihydrotestosterone and 1241- iododeoxyuridine) which will be correlated with pathologic data. A major emphasis will be to assure a physiologically appropriate environment during imaging studies (temperature control, heart and respiratory rate). Construction of a radiofrequency resonator designed to image multiple mice simultaneously with inhalation anesthesia, temperature monitoring etc. will be done. To enhance spatial resolution, more sensitive resonators coils will be investigated. As a core facility, the main goal will be to provide state of the art imaging capability, improvements in image processing and analysis to enhance the accuracy of multimodality imaging (supported in collaboration with other grants), and appropriate radiotracers which will be provided by the Cyclotron and Radiochemistry Core of Memorial Sloan Kettering Cancer Center