TRAINING IN MOLECULAR AND CELL BIOLOGY OF ALLERGY

这个三机构培训方案是在1992年后期组织的，1994年7月开始由NIAID提供资金。它利用了拉霍亚科学界广泛的过敏研究活动。教职员工来自三个相邻的研究所-拉霍亚过敏和免疫学研究所（LIAI），斯克里普斯研究所（TSRI）和加州大学圣地亚哥分校（UCSD）。这三个中心的研究重点不同，但有一个共同的目标。总之，这两个研究领域几乎涵盖了过敏研究中的所有主要问题。因此，学员将有机会接触到广泛的研究课题。此外，机构间培训计划还可以促进来自不同机构的研究人员之间的互动和合作。所有教师都有完善的研究计划；他们的研究背景是多样化的，当综合起来包括免疫学，生物化学，细胞生物学和分子生物学。因此，这个培训项目代表了一个跨学科的方法。学员可参与以下研究领域：1)IgE产生调控，包括Th1/Th2分化；2)炎性细胞生物学，包括肥大细胞和嗜酸性粒细胞；3) T细胞生物学；4)与过敏反应密切相关的细胞受体；5)信号转导；6)炎症介质/细胞因子；7)上皮细胞的功能；7)细胞粘附。该计划的目标是：1)使学员对过敏性疾病的发病机制有基本的了解；2)培养学员的研究技能，特别是运用分子和细胞生物学方法研究疾病的机制。该项目面向对疾病导向问题感兴趣并致力于临床科学基础研究的博士和医学博士。预期受训者将把全部时间用于研究，训练将由会议、讨论会、期刊俱乐部和课程补充。可以预期，学员将在变态反应疾病的发病机制和变态反应炎症的分子和细胞机制方面发展坚实的背景，并成为合格和自信的开始他们作为变态反应研究独立研究者的职业生涯。受训者获得的广泛专业知识和经验将为他们在一般生物医学领域的独立研究做好准备。

This tri-institutional training program was organized in late 1992 and the funding by NIAID began in July 1994. It takes advantage of the combined extensive allergy research activities in the La Jolla scientific community. The faculty members are from three neighboring institutes- La Jolla Institute for Allergy and Immunology (LIAI), The Scripps Research Institute (TSRI), and University of California, San Diego (UCSD). The three centers have different research emphases, while sharing a common goal. Together, the research areas encompass nearly all the major issues in allergy research. Therefore, the trainees will have opportunities to be exposed to a wide range of research topics. In addition, the inter-institutional training program serves as a catalyst for promoting interactions and collaborations among researchers from different institutes. All faculty members have well-established research program; their research backgrounds are diverse and when taken together encompass immunology, biochemistry, cell biology, and molecular biology. Therefore, this training program represents an interdisciplinary approach. The trainees can be involved in the following research areas: 1) regulation of IgE production, including Th1/Th2 differentiation; 2) biology of inflammatory cells, including mast cells and eosinophils; 3) biology of T cells; 4) cell receptors critically involved in allergic reactions; 5) signal transduction; 6) Inflammatory mediators/cytokines; 7) functions of epithelial cells; and 7) cell adhesion. The goals of the program are 1) to provide trainees with a basic understanding of pathogenesis of allergic diseases; and 2) to foster the development of trainee's investigative skills, in particular, applying molecular and cellular biological approaches to study mechanisms of diseases. The program is open to Ph.D.s and M.D.s interesting in disease-oriented problems and committed to career in basic research in clinical sciences. The trainees are expected to devote full time to research, and training will be supplemented by conferences, seminars, journal clubs and courses. It can be expected that trainees will develop a solid background in pathogenesis of allergic diseases and molecular and cellular mechanisms of allergic inflammation and become qualified and confident in embarking upon their careers as independent investigators in allergy research. The broad expertise and experience the trainees acquire will prepare them for independent research in biomedicine in general.