CUE EEG/ERP REACTIVITY PRE AND POST NICOTINE THERAPY

描述：(申请人摘要) 这个项目的目标是描述中枢神经系统的变化。 与成功或失败相关的系统功能和提示反应性 两种疗法：(1)尼古丁贴片加行为疗法(NP BT)和(2) 安慰剂贴片加行为疗法(PP BT)。假设的关系 源自基于神经生物学的成瘾模型，负面情绪， 尼古丁的情况和特性依赖的影响。优先、期间和 在NP BT或PP BT之后，大脑皮质的个体差异 脑活动(背景脑电、诱发脑电和事件相关电位) 将在认知任务期间和对吸烟和 情感暗示。吸烟者的大脑活动将与吸烟成功相关 维持戒烟与戒烟后的影响。个体 情绪、渴望和认知表现的不同将与 这些大脑活动的变化，成功地维持禁欲，以及 与吸烟有关的人格和精神病理学维度。吸烟者(N= 300)将被随机分配到以下三组之一：(1)NP(N=120)， (2)BT(N=120)，或(3)延迟戒烟(DQ，N=60)。DQ小组将会是 用于控制重复暴露(习惯性、重复暴露)的影响 测量效果)到实验评估/刺激。表征 大脑对吸烟和情感暗示反应的变化 与NP Bt和PP Bt相关联的DQ组将有助于阐明 NP BT在某些方面促进比简单PP BT更成功的机制 而在其他人身上却做不到。据预测， 与负面情绪相关的人格维度和倾向 神经精神障碍将不同地预测NP BT的成功 对阵PP BT。预计多元回归和其他 多变量技术将显示使用脑电和事件相关电位测量 在预测治疗成功和治疗x个体方面具有更大的价值 相互作用而不是心率反应。长期目标是 更好地描述大脑和心理机制在何时、在 谁，以及如何有效的NP，BT和BT疗法，以开发更多 有效和个性化的吸烟干预。

DESCRIPTION: (Applicant's Abstract) The goal of this project is to characterize changes in central nervous system functioning and cue reactivity associated with success versus failure of two therapies: (1) nicotine patch plus behavior therapy (NP+BT) and (2) placebo patch plus behavioral therapy (PP+BT). Hypothesized relationships derive from neurobiologically based models of addiction, negative affect, and nicotine's situation and trait-dependent effects. Prior, during, and subsequent to NP+BT or PP+BT, individual differences in electrocortical brain activity (background EEG, evoked EEG, and event-related potential) will be assessed during cognitive tasks and in response to smoking and affective cues. Smokers' brain activity will be related to success in maintaining smoking abstinence and post cessation affect. Individual differences in mood, craving, and cognitive performance will be related to these changes in brain activity, success in maintaining abstinence, and smoking-related dimensions of personality and psychopathology. Smokers (N = 300) will be randomly assigned to one of three groups: (1) NP (N = 120), (2) BT (N = 120), or (3) delayed quit (DQ, N = 60). The DQ group will be used to control for effects of repeated exposure (habituation, repeated measures effects) to the experimental assessments/stimuli. Characterization of changes in brain responses to smoking-related and affective cues associated with NP+BT and PP+BT versus the DQ group will help elucidate mechanisms by which NP+BT facilitates success above simple PP+BT in some individuals while failing to do so in others. It is predicted that negative-affect-related personality dimensions and dispositions to neuropsychiatric disorders will differentially predict success with NP+BT versus PP+BT. It is expected that multiple regression and other multivariate techniques will show the use of EEG and ERP measures to be of greater value in predicting treatment success and treatment x individual interactions than heart-rate responses. The long-term objective is to better characterize brain and psychological mechanisms mediating when, in whom, and how NP+BT and BT therapies are effective, so as to develop more effective and individualized smoking interventions.