CUE EEG/ERP REACTIVITY PRE AND POST NICOTINE THERAPY

描述：（申请人摘要） 该项目的目标是描述中枢神经系统的变化， 与成功和失败相关的系统功能和线索反应 两种疗法：（1）尼古丁贴片加行为疗法（NP+BT）和（2） 安慰剂贴剂+行为疗法（PP+BT）。 假设关系 从神经生物学上的成瘾模型，负面影响， 以及尼古丁的情境和特质依赖效应。 在此之前、期间和 在NP+BT或PP+BT之后，皮层电活动的个体差异 脑活动（背景EEG、诱发EEG和事件相关电位） 将在认知任务中进行评估，并对吸烟做出反应， 情感线索 吸烟者的大脑活动将与成功 保持戒烟和戒烟后的影响。 个人 情绪，渴望和认知表现的差异将与 这些大脑活动的变化，保持禁欲的成功， 吸烟相关的人格和精神病理学维度。 吸烟者（N = 300)将被随机分配到三组之一：（1）NP（N = 120）， (2)BT（N = 120）或（3）延迟退出（DQ，N = 60）。 DQ集团将在 用于控制重复暴露的影响（习惯化，重复 测量效果）到实验评估/刺激。 表征 大脑对与吸烟有关的情感线索的反应 NP+BT和PP+BT与DQ组的相关性将有助于阐明 在某些情况下，NP+BT有助于成功超过简单PP+BT的机制 而在其他人身上却做不到。 据预测 消极情感相关人格维度和倾向 神经精神疾病将差异性地预测NP+BT的成功 对比PP+BT。 预计多元回归和其他 多变量技术将显示使用EEG和ERP测量是可行的。 在预测治疗成功和治疗x个体方面的价值更大 而不是心率反应。 长期目标是 更好地描述大脑和心理机制调解时， 谁，以及如何NP+BT和BT疗法是有效的，以便开发更多 有效和个性化的吸烟干预措施。

DESCRIPTION: (Applicant's Abstract) The goal of this project is to characterize changes in central nervous system functioning and cue reactivity associated with success versus failure of two therapies: (1) nicotine patch plus behavior therapy (NP+BT) and (2) placebo patch plus behavioral therapy (PP+BT). Hypothesized relationships derive from neurobiologically based models of addiction, negative affect, and nicotine's situation and trait-dependent effects. Prior, during, and subsequent to NP+BT or PP+BT, individual differences in electrocortical brain activity (background EEG, evoked EEG, and event-related potential) will be assessed during cognitive tasks and in response to smoking and affective cues. Smokers' brain activity will be related to success in maintaining smoking abstinence and post cessation affect. Individual differences in mood, craving, and cognitive performance will be related to these changes in brain activity, success in maintaining abstinence, and smoking-related dimensions of personality and psychopathology. Smokers (N = 300) will be randomly assigned to one of three groups: (1) NP (N = 120), (2) BT (N = 120), or (3) delayed quit (DQ, N = 60). The DQ group will be used to control for effects of repeated exposure (habituation, repeated measures effects) to the experimental assessments/stimuli. Characterization of changes in brain responses to smoking-related and affective cues associated with NP+BT and PP+BT versus the DQ group will help elucidate mechanisms by which NP+BT facilitates success above simple PP+BT in some individuals while failing to do so in others. It is predicted that negative-affect-related personality dimensions and dispositions to neuropsychiatric disorders will differentially predict success with NP+BT versus PP+BT. It is expected that multiple regression and other multivariate techniques will show the use of EEG and ERP measures to be of greater value in predicting treatment success and treatment x individual interactions than heart-rate responses. The long-term objective is to better characterize brain and psychological mechanisms mediating when, in whom, and how NP+BT and BT therapies are effective, so as to develop more effective and individualized smoking interventions.