Combining advanced polymer-peptide conjugate synthesis with advanced mass spectrometry characterization - a collaborative study.

将先进的聚合物-肽缀合物合成与先进的质谱表征相结合——一项合作研究。

• 批准号: 1837376
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1837376
• 关键词: Combining; advanced; polymer; peptide; conjugate

This project involves study of synthesis and characterisation of polymer-peptide self-assembling conjugates using advanced mass spectrometry methods. The methods to be used include ultra high resolution mass spectrometry, advanced tandem mass spectrometry (ExD, IRMPD, CAD), and two dimensional mass spectrometry. In addition to allowing better control of the chemistry of synthesis of these materials, the advanced analytical methods should allow far more comprehensive data than ever previously achieved on polymeric materials.This project is a collaborative project among Prof. Peter O'Connor, Prof. Sebastien Perrier, and Dr. Anthony Bristow at Astra Zeneca in Macclesfield.

该项目涉及使用先进的质谱方法研究聚合物-肽自组装缀合物的合成和表征。使用的方法包括超高分辨率质谱、高级串联质谱（ExD、IRMPD、CAD）和二维质谱。除了可以更好地控制这些材料的化学合成，先进的分析方法应该允许更全面的数据比以往任何时候都在聚合物materials.This项目是一个合作项目之间的教授彼得奥康纳，教授Patitien Perrier，和博士安东尼布里斯托在阿斯利康麦克尔斯菲尔德。

项目成果

Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

• DOI: 10.1039/d0cc03548c
• 发表时间: 2020-09-04
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Lam, Yuko P. Y.;Chiu, Cookson K. C.;O'Connor, Peter B.
• 通讯作者: O'Connor, Peter B.

New activation mechanism for half-sandwich organometallic anticancer complexes.

• DOI: 10.1039/c7sc05058e
• 发表时间: 2018-03-28
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Banerjee S;Soldevila-Barreda JJ;Wolny JA;Wootton CA;Habtemariam A;Romero-Canelón I;Chen F;Clarkson GJ;Prokes I;Song L;O'Connor PB;Schünemann V;Sadler PJ
• 通讯作者: Sadler PJ

Bottom-Up Two-Dimensional Electron-Capture Dissociation Mass Spectrometry of Calmodulin

• DOI: 10.1007/s13361-017-1812-y
• 发表时间: 2018-01-01
• 期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
• 影响因子: 3.2
• 作者: Floris, Federico;van Agthoven, Maria A.;O'Connor, Peter B.
• 通讯作者: O'Connor, Peter B.

Metallocomplex-Peptide Interactions Studied by Ultrahigh Resolution Mass Spectrometry

• DOI: 10.1021/jasms.9b00054
• 发表时间: 2020-03-01
• 期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
• 影响因子: 3.2
• 作者: Chiu, Cookson K. C.;Lam, Yuko P. Y.;O'Connor, Peter B.
• 通讯作者: O'Connor, Peter B.

Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?

• DOI: 10.1039/c8cc06675b
• 发表时间: 2018-12-21
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Lam, Yuko P. Y.;Wootton, Christopher A.;O'Connor, Peter B.
• 通讯作者: O'Connor, Peter B.