Visual Signals and Social Behavior

视觉信号和社会行为

• 批准号: 6445070
• 负责人: Wayne Joseph Korzan
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-05 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6445070
• 关键词: aggression; amines; behavior test; behavioral /social science research tag; biological signal transduction; brain; catecholamines; dissection; electrochemistry; high performance liquid chromatography; hippocampus; lizards; neuroendocrine system; psychological stressor; social behavior; social status; sympathetic nervous system; visual perception

DESCRIPTION (provided by applicant): The objective of the proposed experiments is to determine the neuroendocrine mechanisms linking aggression, social status and stress. In humans and other vertebrates, stress from aggression or low social status results in highly modified behavior and emotional dysfunction, such as depression. A model system with relatively simple behavior and a visible indicator of stress responsiveness, provides a mechanism for studying complex integration of autonomic and limbic systems with brainstem monoamine perikarya and peripheral stress responses. In Anolis carolinensis, a unique sign stimulus, the formation of postorbital eyespots, appears to be directly related to social status. Therefore, altering the formation of the eyespot using either physical or pharmacological manipulations should influence social status. Specific Aims: This proposal will ivestigate four related objectives. The first objective is to determine the relative influence of the eyespot as a social signal. Second, determining the value of the eyespot as a social signal in previously established social hierarchies adds the test of reversal of dominance. The eyespot, as a social signal, may override previously established social status. Third, is determining the relationships among eyespot formation, aggression and monoamine release in hippocampus, testing if in specific nuclei (e.g. hippocampus) 5-HT and DA are inversely related to one another with respect to behavior. Microdialysis will be utilized to measure serotonergic and dopaminergic activity during aggressive interactions. The fourth objective is to learn if there is a direct reciprocal regulation of hippocampal dopamine and serotonin.

描述（由申请人提供）：拟议实验的目的 是为了确定与攻击性和社会地位联系起来的神经内分泌机制 和压力。在人类和其他脊椎动物中，来自攻击性或低水平的压力 社会地位导致行为高度改变和情绪功能障碍， 比如抑郁症。具有相对简单行为和 压力反应能力的可见指标，提供了一种研究机制 自主神经和边缘系统与脑干单胺的复杂整合 核周和外周应激反应。在卡罗莱纳安乐蜥 (Anolis carolinensis) 中，有一种独特的 信号刺激，即眶后眼斑的形成，似乎直接 与社会地位有关。因此，改变眼斑的形成 使用物理或药物操作应该影响社会 地位。 具体目标：该提案将调查四个相关目标。第一个 目的是确定眼点作为社会因素的相对影响力 信号。其次，确定眼点作为社交信号的价值 先前建立的社会等级制度增加了逆转的考验 统治地位。眼点作为一种社交信号，可能会推翻之前建立的信号 社会地位。第三，确定眼斑形成之间的关系， 海马体的攻击性和单胺释放，测试是否在特定的细胞核中 （例如海马）5-HT 和 DA 彼此呈负相关，其中 对行为的尊重。微透析将用于测量血清素能和 攻击性互动期间的多巴胺能活动。第四个目标是 了解海马多巴胺是否存在直接相互调节 血清素。