Social Regulation of GnRH Release

GnRH 释放的社会调节

基本信息

  • 批准号:
    7234277
  • 负责人:
  • 金额:
    $ 5.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-05-12 至 2008-05-11
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by candidate): The proposed experiments are designed to understand how social interactions produce functional changes in the central nervous system. As a model system for studying this work, I will use an African cichlid fish species, Haplochromis burtoni, in which previous work has shown that the size of gonadotropin releasing hormone (GnRH) neurons in the preoptic area (POA) in males depends on social status. Dominant males have large GnRH neurons with elaborated processes while non-dominant animals have small neurons with reduced processes. The size and neural activity of these GnRH neurons corresponds directly with the individual's reproductive potential, namely dominant males can reproduce while non-dominant animals cannot. However, the neural mechanisms through which social and environmental conditions regulate GnRH neurons and hence reproduction are not known. In many species, changes in levels of the neurotransmitters serotonin (5-HT) and dopamine (DA) are related to changes in behavior and social (e.g. rank and reproductive) status. Moreover, 5-HT cells and fibers have been found in close proximity to GnRH neurons in the preoptic area (POA) as has also been shown for dopamine immunoreactive neurons in teleost fish, amphibians and birds. Recently, dopamine has been shown to influence the electrical activity of GnRH cells in the POA of Haplochromis burtoni. The experiments proposed here are designed to understand the role of serotonin and dopamine in regulating behavior, social rank and GnRH neuron size and activity. The expected results will contribute to our understanding of how neural plasticity both control and depend on social behavior.
描述(由Candiate提供):拟议的实验旨在了解社交互动如何产生中枢神经系统的功能变化。作为研究这项工作的模型系统,我将使用一种非洲慈鱼物种Haplochromis burtoni,在该物种中,先前的研究表明,雄性视前区(POA)中促性腺激素释放激素(GnRH)神经元的大小取决于社会地位。优势雄性有大的GnRH神经元,具有精细的突起,而非优势的动物有小的神经元,突起减少。这些促性腺激素释放激素神经元的大小和神经活动与个体的生殖潜力直接对应,即占优势的雄性可以繁殖,而非占优势的动物不能。然而,社会和环境条件调节GnRH神经元从而繁殖的神经机制尚不清楚。在许多物种中,神经递质5-羟色胺(5-羟色胺)和多巴胺(DA)水平的变化与行为和社会(例如等级和生殖)地位的变化有关。此外,与硬骨鱼、两栖动物和鸟类的多巴胺免疫反应神经元一样,5-羟色胺细胞和纤维也被发现与视前区的GnRH神经元非常接近。最近,多巴胺被证明影响伯顿单色鱼POA中GnRH细胞的电活动。这里提出的实验旨在了解5-羟色胺和多巴胺在调节行为、社会地位以及GnRH神经元大小和活动方面的作用。预期的结果将有助于我们理解神经可塑性如何控制和依赖社会行为。

项目成果

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Wayne Joseph Korzan其他文献

Wayne Joseph Korzan的其他文献

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{{ truncateString('Wayne Joseph Korzan', 18)}}的其他基金

Social Regulation of GnRH Release
GnRH 释放的社会调节
  • 批准号:
    7105480
  • 财政年份:
    2005
  • 资助金额:
    $ 5.1万
  • 项目类别:
Social Regulation of GnRH Release
GnRH 释放的社会调节
  • 批准号:
    6936713
  • 财政年份:
    2005
  • 资助金额:
    $ 5.1万
  • 项目类别:
Visual Signals and Social Behavior
视觉信号和社会行为
  • 批准号:
    6651646
  • 财政年份:
    2002
  • 资助金额:
    $ 5.1万
  • 项目类别:
Visual Signals and Social Behavior
视觉信号和社会行为
  • 批准号:
    6528992
  • 财政年份:
    2002
  • 资助金额:
    $ 5.1万
  • 项目类别:
Visual Signals and Social Behavior
视觉信号和社会行为
  • 批准号:
    6445070
  • 财政年份:
    2001
  • 资助金额:
    $ 5.1万
  • 项目类别:

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