CORE-- NEUROPATHOLOGY

核心——神经病理学

• 批准号: 6482386
• 负责人: WILLIAM ELLIS
• 金额: $ 38.95万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6482386
• 关键词: Alzheimer's disease; Lewy body; biomedical facility; brain; brain disorder diagnosis; cerebrovascular disorders; dementia; diagnosis design /evaluation; disease /disorder classification; disease /disorder etiology; genetic registry /resource /referral center; histopathology; human subject; immunocytochemistry; information dissemination; neural degeneration; neuritic plaques; neurofibrillary tangles; neuropathology; pathologic process; patient oriented research; postmortem; tissue /organ preservation; tissue resource /registry

The UC Davis Alzheimer's Disease Center Neuropathology Core has its overall goal to define the cause of dementia during life and to relate findings obtained during life, such as clinical diagnoses, cognitive function measurements, and neuroimaging to neuropathological substrates. The major goals are to obtain brain autopsies in ADC patients and controls that have been clinically evaluated in the longitudinal cohort, describe and diagnoses all brain lesions found at autopsy, especially changes related to AD pathology and cerebrovascular pathology, correlate these neuropathological diagnoses with the clinical and neuroimaging findings in each patient, and offer well-preserved autopsy brain tissues to research workers in our own and other institutions. The Neuropathology Core will continue the previous practice of working closely with the Clinical Core to ensure that autopsies are obtained on subjects of interest. This includes those individuals enrolled in the Longitudinal Cohort who are particularly likely to also show pathological changes related to cerebrovascular disease (CVD). The Neuropathology Core has developed, and will continue to refine, methods to chart the location and severity of CVD post mortem in the expectation that this precise level of analysis will permit us to improve our ability to partition the relative importance of Alzheimer and cerebrovascular changes to causing the dementia. In addition to these measurements of CVD the core will make measurements of AD and Lewy body pathology using standardized criteria, and will seek to carefully describe the pathological findings in other and unusual causes of dementia. Other important features of the Core are regular clinicopathological conferences, a hierarchical approach to dementia diagnosis when mixed causes are present, a large and well-documented inventory of tissue samples, and a detailed database that is fully integrated with the Biostatistics and Data Management Core.

加州大学戴维斯分校阿尔茨海默病中心神经病理学核心的总体目标是定义生活中痴呆的原因，并将生活中获得的发现，如临床诊断，认知功能测量和神经影像学与神经病理学底物联系起来。主要目标是获得已在纵向队列中进行临床评估的ADC患者和对照组的脑部尸检，描述和诊断尸检时发现的所有脑部病变，特别是与AD病理学和脑血管病理学相关的变化，将这些神经病理学诊断与临床相关联。和神经影像学发现在每名患者中，并为我们自己和其他机构的研究人员提供保存完好的尸检脑组织。神经病理学核心将继续与临床核心密切合作，以确保对感兴趣的受试者进行尸检。这包括那些在纵向队列中登记的个体，他们特别可能也表现出与脑血管疾病（CVD）相关的病理变化。神经病理学核心已经开发出并将继续完善绘制死后CVD的位置和严重程度的方法，期望这种精确的分析水平将使我们能够提高我们划分阿尔茨海默病和脑血管变化导致痴呆的相对重要性的能力。除了CVD的这些测量之外，核心还将使用标准化标准测量AD和路易体病理学，并将寻求仔细描述痴呆症的其他和不寻常原因的病理学发现。该核心的其他重要特征是定期的临床病理会议，当存在混合原因时痴呆诊断的分层方法，大量且记录良好的组织样本库存，以及与生物统计学和数据管理核心完全集成的详细数据库。