CORE-- NEUROPATHOLOGY

神经病理核心将协调大脑的尸检取回 来自临床核心研究的患者，并将解剖和保存 这些大脑在解剖学上是精确的。这将允许 多重免疫细胞化学、分子生物学和免疫组织化学的应用 对特定大脑区域的生化程序也已经被 对阿尔茨海默病进行半定量组织学评估 异常(老年斑、神经原纤维缠结、神经元丢失、 异常轴突)使用银染、染色和免疫染色；测量 老年性斑块；斑块类型的分类计数；以及生化 胆碱乙酰转移酶和阿尔茨海默病相关蛋白的测定。这个 神经病理和生化评估的结果将被比较 并进行临床/神经成像评估，以便 评估诊断准确性并确定疾病的神经病理指标 与认知缺陷相关的严重性和局部性。这些 比较将测试评估的准确性，并提供 与科学家合作研究了大量经过充分研究的脑组织 已知的病理类型和程度。

The Neuropathology Core will coordinate post-mortem retrieval of brains from patients studied in the Clinical Core and will dissect and preserve these brains in an anatomically precise manner. This will permit application of multiple immunocytochemical, molecular biological and biochemical procedures to specific brain regions that also have been subjected to semi-quantitative histologic assessment of Alzheimer's disease abnormalities (senile plaques, neurofibrillary tangles, neuronal loss, abnormal neurites) using silver, tinctorial and immunostaining; measurement of senile plaque; differential counts of plaques by type; and biochemical assay of choline acetyltransferase and Alzheimer-related proteins. The results of the neuropathologic and biochemical assessments will be compared with each other and with clinical/neuroimaging assessments in order to assess diagnostic accuracy and identify neuropathologic indices of disease severity and localication that correlate with cognitive defects. These comparisons will test the accuracy of the assessments and provide to collaborating scientists large amounts of well studied brain tissue with a known type and degree of pathology.