Effects of exercise and lifestyle management on reproductive function in overweight women with polycystic ovary syndrome

多囊卵巢综合征(PCOS)是一种复杂的疾病，在5-10%的育龄妇女中存在。它与肥胖、月经障碍增加和不孕不育以及代谢状况有关，如血清胰岛素升高、高胆固醇、糖尿病和心脏病。旨在减少肥胖和胰岛素抵抗的生活方式干预措施，包括饮食减肥和体力活动，被倡导用于多囊卵巢综合征的管理。然而，尽管研究表明，通过饮食减肥可以改善许多症状，但很少有研究评估体育锻炼在管理这一状况方面的综合作用。此外，没有研究探讨为实现长期生殖健康和代谢健康而应采取的最佳运动形式，因此缺乏针对多囊卵巢综合征患者的循证运动指南。我们计划进行一项临床研究，以调查在多囊卵巢综合征患者中，结合运动和节食减肥是否在改善月经功能、生育力和代谢健康方面提供了任何额外的好处，而不是仅仅使用饮食限制。我们还将评估，当与饮食限制相结合时，同时包括耐力运动和抗阻运动的体力活动计划是否比更常见的仅有耐力运动的处方提供更大的好处。这些信息将被用来帮助制定有效管理多囊卵巢综合征患者生殖功能障碍的指南。

Polycystic ovary syndrome (PCOS) is a complex disorder present in 5-10% of women of reproductive age. It is associated with obesity, increased menstrual dysfunction and infertility and metabolic conditions such as increased serum insulin, high cholesterol, diabetes and heart disease. Lifestyle interventions aimed at reducing obesity and insulin resistance, which include dietary weight loss and physical activity, are advocated for the management of PCOS. However, while research indicates that weight loss through diet improves many symptoms, there is a paucity of research evaluating the combined role of physical exercise in managing this condition. In addition, there is no research examining the optimal form of exercise that should be undertaken to achieve long-term reproductive fitness and metabolic health and consequently there is a lack of evidence-based exercise guidelines for patients with PCOS. We plan to perform a clinical study to investigate whether combining exercise with weight loss by diet in patients with PCOS provides any additional benefit for improving menstrual function, fertility and metabolic health beyond those that can be achieved using dietary restriction alone. We will also assess whether, when combined with dietary restriction, a program of physical activity incorporating both endurance and resistance exercise provides a greater benefit than the more common prescription of endurance exercise alone. This information will be used to assist in the development of guidelines for the effective management of reproductive dysfunction in patients with PCOS.