Effects of exercise and lifestyle management on reproductive function in overweight women with polycystic ovary syndrome

运动和生活方式管理对超重多囊卵巢综合征女性生殖功能的影响

• 批准号: nhmrc : 401817
• 负责人: A/Pr Grant Brinkworth
• 金额: $ 25.32万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-exercise-lifestyle-ovary-syndrome/82551
• 关键词: Effects; exercise; lifestyle; management; reproductive

Polycystic ovary syndrome (PCOS) is a complex disorder present in 5-10% of women of reproductive age. It is associated with obesity, increased menstrual dysfunction and infertility and metabolic conditions such as increased serum insulin, high cholesterol, diabetes and heart disease. Lifestyle interventions aimed at reducing obesity and insulin resistance, which include dietary weight loss and physical activity, are advocated for the management of PCOS. However, while research indicates that weight loss through diet improves many symptoms, there is a paucity of research evaluating the combined role of physical exercise in managing this condition. In addition, there is no research examining the optimal form of exercise that should be undertaken to achieve long-term reproductive fitness and metabolic health and consequently there is a lack of evidence-based exercise guidelines for patients with PCOS. We plan to perform a clinical study to investigate whether combining exercise with weight loss by diet in patients with PCOS provides any additional benefit for improving menstrual function, fertility and metabolic health beyond those that can be achieved using dietary restriction alone. We will also assess whether, when combined with dietary restriction, a program of physical activity incorporating both endurance and resistance exercise provides a greater benefit than the more common prescription of endurance exercise alone. This information will be used to assist in the development of guidelines for the effective management of reproductive dysfunction in patients with PCOS.

多囊卵巢综合征（PCOS）是一种复杂的疾病，存在于5-10%的育龄妇女中。它与肥胖、月经功能障碍加剧、不孕症和代谢状况（如血清胰岛素升高、高胆固醇、糖尿病和心脏病）有关。生活方式干预旨在减少肥胖和胰岛素抵抗，包括饮食减肥和体育活动，提倡多囊卵巢综合征的管理。然而，虽然研究表明，通过饮食减肥可以改善许多症状，但缺乏评估体育锻炼在控制这种情况中的综合作用的研究。此外，目前还没有研究检验实现长期生殖健康和代谢健康的最佳运动形式，因此缺乏针对多囊卵巢综合征患者的循证运动指南。我们计划开展一项临床研究，以调查在PCOS患者中，运动与饮食减肥相结合是否能在改善月经功能、生育能力和代谢健康方面提供任何额外的益处，而不仅仅是单独使用饮食限制。我们还将评估，当与饮食限制相结合时，结合耐力和阻力运动的体育活动计划是否比单独进行更常见的耐力运动处方更有益。这些信息将用于协助制定有效管理多囊卵巢综合征患者生殖功能障碍的指南。