Cognitive and neural mechanisms underlying the relationship between Attention Deficit Hyperactivity Disorder and disordered eating behaviour

注意力缺陷多动障碍与饮食行为失调之间关系的认知和神经机制

• 批准号: 1915105
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1915105
• 关键词: Cognitive; neural; mechanisms; underlying; relationship

Disordered eating behaviour is a common comorbidity of attention deficit hyperactivity disorder (ADHD). Previous research has linked specific symptoms of ADHD (e.g. inattention, impulsivity) to specific types of disordered eating behaviour, and these relationships seem to be mediated through both negative mood and through attention to and reliance on internal cues of hunger and satiety. This PhD project will further investigate the mechanisms through which specific symptoms of ADHD lead to specific types of disordered eating. The project will first assess how inattention towards interoceptive cues of satiety/hunger may lead to disordered eating behaviour, through the completion of a systematic literature review and laboratory-based eating behaviour studies. The nature of the relationship between ADHD symptoms and disordered eating behaviour will then be assessed through the use of Lisdexamfetamine, a drug used in the treatment of both ADHD and binge eating disorder. This will allow the observation of the specific ADHD symptoms which are influenced by LDX, and how this effect may mediate the action of LDX on binge eating. The project will also assess the relationship between ADHD symptomatology and disordered eating behaviour in adolescents, which is of particular interest as ADHD symptomatology changes at this age and disordered eating patterns may emerge. This will be achieved through longitudinal collection of survey data, allowing the predictive modelling of which ADHD symptoms are most predictive of the development of disordered eating behaviour, which will be potentially useful in guiding development of preventative measures. A further laboratory-based eating behaviour study will assess the relationship between ADHD symptoms and disordered eating behaviour in adolescence, to observe how the longitudinal survey results are consistent with effects on ad libitum food intake.

饮食行为障碍是注意缺陷多动障碍（ADHD）的常见合并症。先前的研究已经将ADHD的特定症状（例如注意力不集中，冲动）与特定类型的饮食失调行为联系起来，这些关系似乎通过负面情绪以及对饥饿和饱腹感的内部线索的关注和依赖来介导。这个博士项目将进一步研究ADHD的特定症状导致特定类型的饮食失调的机制。该项目将首先通过完成系统的文献综述和基于实验室的饮食行为研究，评估对饱腹感/饥饿感的内感受线索的忽视如何导致饮食行为紊乱。然后，将通过使用Lisdexamfetamine（一种用于治疗ADHD和暴食症的药物）来评估ADHD症状和饮食行为紊乱之间关系的性质。这将允许观察受LDX影响的特定ADHD症状，以及这种影响如何介导LDX对暴饮暴食的作用。该项目还将评估ADHD运动学与青少年饮食行为紊乱之间的关系，这一点特别令人感兴趣，因为ADHD运动学在这个年龄段发生变化，可能会出现饮食紊乱。这将通过纵向收集调查数据来实现，从而可以预测哪些ADHD症状最能预测饮食失调行为的发展，这将有助于指导预防措施的制定。一项进一步的基于实验室的饮食行为研究将评估ADHD症状与青春期饮食行为紊乱之间的关系，以观察纵向调查结果如何与随意食物摄入的影响一致。

项目成果

Associations between inattention and impulsivity ADHD symptoms and disordered eating risk in a community sample of young adults.

• DOI: 10.1017/s0033291720004638
• 发表时间: 2022-10
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Martin E;Dourish CT;Hook R;Chamberlain SR;Higgs S
• 通讯作者: Higgs S

The effects of lisdexamfetamine dimesylate on eating behaviour and homeostatic, reward and cognitive processes in women with binge-eating symptoms: an experimental medicine study.

• DOI: 10.1038/s41398-021-01770-4
• 发表时间: 2022-01-10
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Schneider E;Martin E;Rotshtein P;Qureshi KL;Chamberlain SR;Spetter MS;Dourish CT;Higgs S
• 通讯作者: Higgs S