Novel nucleic acid chemical modifications for the development of in vitro diagnostics using synthetic biology approaches

利用合成生物学方法开发体外诊断的新型核酸化学修饰

• 批准号: 1915128
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1915128
• 关键词: Novel; nucleic; acid; chemical; modifications

Developing new chemical modifications and methodologies for nucleic acids that will be coupled with new and existing diagnostic platforms. This will include the use of Linear Diagnostics' patented platform which uses synthetic biology to modify bacteriophage to recognise targets of interest in a wide range of sectors. These sectors include agriculture, medicine, food safety, defence and security, veterinary and environmental.

为核酸开发新的化学修饰和方法，将与新的和现有的诊断平台相结合。这将包括使用Linear Diagnostics的专利平台，该平台使用合成生物学来修饰噬菌体，以识别广泛领域的目标。这些部门包括农业、医药、食品安全、国防和安全、兽医和环境。

项目成果

Combining bacteriophage engineering and linear dichroism spectroscopy to produce a DNA hybridisation assay.

• DOI: 10.1039/d0cb00135j
• 发表时间: 2020-12-01
• 期刊: RSC chemical biology
• 影响因子: 4.1
• 作者: Ali A;Little HA;Carter JG;Douglas C;Hicks MR;Kenyon DM;Lacomme C;Logan RT;Dafforn TR;Tucker JHR
• 通讯作者: Tucker JHR

Sub-5-minute Detection of SARS-CoV-2 RNA using a Reverse Transcriptase-Free Exponential Amplification Reaction, RTF-EXPAR

使用无逆转录酶指数扩增反应 RTF-EXPAR 在 5 分钟内检测 SARS-CoV-2 RNA

• DOI: 10.1101/2020.12.31.20248236
• 发表时间: 2021
• 作者: Carter J