UCSF CC/SFSU Collaborative--Cancer Research and Training

UCSF CC/SFSU 合作--癌症研究和培训

• 批准号: 6634054
• 负责人: JOHN A WATSON
• 金额: $ 7.38万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634054
• 关键词: fungal genetics; vertebrate embryology

This Collaborative is between the University of California, San Francisco Cancer Center (UCSFCC) and San Francisco State University (SFSU). It will initiate two pilot Research Projects and two Planning and Development activities for collaborative undergraduate and/or pre- doctoral research training in cancer biology. The collaborative pilot Research Projects will involve two teams of SFSU/UCSFCC investigators; both collaborations will consist of a newly hired SFSU. Assistant Professor of Biology and a senior UCSF faculty member who is also a member of the UCSFCC. UCSF Professor Elizabeth Blackburn, Ph.D. will serve as mentor and co-investigator with Sally Pasion, Ph.D. to characterize telomere ends in fission yeast DNA replication and repair mutant. Wilfred Denetclaw, Ph.D. (appointment as a SFSU Assistant Professor of Biology effective September 2000) will be mentored by his former UCSF post-doctoral supervisor Professor Charles Ordahl. Their collaborative Research Project will focus on the biological markers for dermomyotomal myotome progenitor cells and their epithelial-to-mesenchymal transition into the myotome layer. The research questions and mentoring commitments built into each collaborative pilot Research project are designed to result in the submission of RO1 proposals during the third year of this P-20 planning grant. Student research training will be the focus for the Planning and Development section of this proposal. One pilot Planning and Development activity will use a joint SFSU and UCSFCC faculty committee to develop a more aggressive and concerted placement process/program to recruit SFSU undergraduate (MARC and MBRS- RISE) and SFSU MA/MS degree (NIH Bridge and MBRS-RISE) students into UCSFCC laboratories specifically will review and evaluate the past involvement of, 1) SFSU undergraduates (MARC and MBRS- RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU RISE) in UCSF summer research experiences and 2) the academic year thesis research experiences of SFSU MA/MS degree students whose research was executed in UCSF faculty laboratories as a basis to develop an action plan that will provide an excellent training experience in an environment permeated with a cancer biology focus. The second pilot Planning and Development activity will be directed at doing the ground work necessary to develop a joint R-25E or R-25T or T- 32 pre-doctoral training proposal during the third year of this P-20 project. Realization of this goal will require serious planning through joint UCSFCC-SFSU faculty meetings and retreats to 1) identify and prioritize short and long-term pre-doctoral student cancer research training goals and 2) develop a mutually acceptable collaborative pre- doctoral cancer research training program within the guidelines of a R- 25E or R-25T or T-32 funding mechanism. A core element of any final proposal will be the application of recruitment and retention strategies that will result in an increased enrollment of under-represented strategies that will result in an increased enrollment of under-represented minorities into and graduation from Ph.D. programs.

该合作项目是加州大学旧金山癌症中心(UCSFCC)和旧金山州立大学(SFSU)之间的合作项目。它将启动两个试点研究项目和两个规划和开发活动，以开展癌症生物学方面的本科生和/或博士前研究协作培训。合作试点研究项目将涉及SFSU/UCSFCC调查人员的两个小组；两个合作将由新雇用的SFSU组成。生物学助理教授，加州大学旧金山分校资深教员，也是UCSFCC的成员。加州大学旧金山分校教授伊丽莎白·布莱克本博士将与萨利·帕森博士共同担任导师和研究员，以表征裂解酵母DNA复制和修复突变中的端粒末端。威尔弗雷德·德内特克劳博士(自2000年9月起被任命为旧金山州立大学生物学助理教授)将由他以前的加州大学旧金山分校博士后导师查尔斯·奥尔达尔教授指导。他们的合作研究项目将专注于皮肤肌瘤肌小节前体细胞的生物标记物以及它们从上皮到间充质向肌小肌层的转变。每个合作先导研究项目的研究问题和指导承诺旨在导致在P-20规划赠款的第三年期间提交RO1提案。学生研究培训将是本提案规划和发展部分的重点。一项试点规划和开发活动将使用SFSU和UCSFCC教职员工委员会来制定更积极和协调的安置程序/计划，以招募SFSU本科生(MARC和MBRS-RISE)和SFSU MA/MS学位(NIH Bridge和MBRS-RISE)学生进入UCSFCC实验室，具体将审查和评估过去参与的情况，1)旧金山州立大学本科生(MARC和MBR-RISE)在加州大学旧金山分校的暑期研究经验和2)旧金山州立大学硕士/硕士学位学生在加州大学教授实验室进行的学年论文研究经验，作为制定行动计划的基础，该行动计划将在充满癌症生物学重点的环境中提供出色的培训经验。第二项试点规划和发展活动将旨在开展必要的基础工作，以便在该P-20项目的第三年期间制定R-25E或R-25T或T-32联合博士前培训提案。要实现这一目标，需要通过UCSFCC-SFSU联合教职员工会议和务虚会进行认真规划，以1)确定短期和长期博士前学生癌症研究培训目标并确定其优先顺序，2)在R-25E或R-25T或T-32资助机制的指导下制定双方都能接受的协作性博士前癌症研究培训计划。任何最终提案的一个核心要素将是应用招聘和保留战略，这将导致更多代表不足的战略的招生，这将导致更多代表不足的少数族裔进入博士课程并毕业。