DEVELOPING VIRTUAL COLONOSCOPY FOR CANCER SCREENING

描述(逐字摘自申请者摘要)：结直肠癌 第三种最常见的癌症和第二大致死原因 在美国罹患癌症。它通常在晚期被诊断出来， 在患者出现症状后，解释其高死亡率。 由于大多数癌症都是在5到15年的恶化期内发生的息肉 转化，筛查计划以检测小于1厘米的细小息肉 直径一直被提倡。不幸的是，大多数人没有遵循这一点 建议。这个项目与健康的关系是戏剧性的 通过以下方式增加愿意参加筛查计划的人数 使用一种方便的、几乎没有风险的程序。 虚拟结肠镜检查是一种新的检查方法，在这种检查方法中， 取病人的腹部，并使用计算机可视化系统 在构建的结肠三维模型中进行虚拟导航。宽阔的， 这项建议的长期目标是将虚拟结肠镜检查作为一种 精准、经济实惠、非侵入性、舒适的大屏幕技术 人口的一部分。 为了进一步推进这项技术，这项建议的具体目标是：(1) 开发使用肠道准备方法的电子结肠清洁和 计算机分割技术，(2)研究生成 飞行路线和导航环境，以及纠正结肠塌陷，(3) 通过各种交互式功能优化自动、实时体绘制 用于分析可疑异常的控制，以及(4)确定 虚拟结肠镜检查与光学结肠镜检查的准确性比较。 研究设计和方法将包括评估 在正常的大学年龄志愿者中，通过观察以下内容来电子清洁结肠 连续几天进行虚拟结肠镜检查的可行性 通过记录以下内容将技术带到易于访问的环境 通过结肠制作的导航的处理速度和质量；以及 实时体绘制算法的精确度比较 改良结肠光学结肠镜检查同一患者息肉 大便/液体标记口服造影剂的制备。

DESCRIPTION (Verbatim from the Applicant's Abstract): Colorectal carcinoma is the third most commonly diagnosed cancer and the second leading cause of death from cancer in the United States. Often it is diagnosed at an advanced stage, after the patient has developed symptoms, explaining its high mortality rate. Since most cancers arise from polyps over a 5 to 15 year period of malignant transformation, screening programs to detect small polyps less than 1 cm in diameter have been advocated. Unfortunately most people do not follow this recommendations. The health relatedness of this project is to dramatically increase the number of people willing to participate in screening programs by using a convenient, nearly risk-free procedure. Virtual colonoscopy is a new procedure in which computed tomographic images of the patient's abdomen are taken and a computer visualization system is used to virtually navigate within a constructed 3-D model of the colon. The broad, long-term objective of this proposal is to develop virtual colonoscopy as an accurate7 costeffective, non-invasive, comfortable technique to screen large segments of the population. To further advance this technology, the specific aims of this proposal are: (1) to develop electronic colon cleansing using bowel preparation methods and computer segmentation techniques, (2) to investigate means for generating a flight-path and a navigation environment, and correcting colon collapse, (3) to optimize automatic, real-time volume rendering with various interactive controls for analysis of suspected abnormalities, and (4) to determine the accuracy of virtual colonoscopy compared to optical colonoscopy. The research design and methodology will include evaluating the ability to electronically clean the colon in normal, college-aged volunteers by looking at virtual colonoscopy procedures performed on consecutive days; the feasibility of bringing the technology to a readily accessible environment by documenting the processing speed and quality of produced navigation through the colon; and the accuracy of real-time volume-rendering algorithms by comparing virtual and optical colonoscopy polyp detection in the same patient using a modified colon preparation with stool/fluid labeling oral contrast solutions.