TRAINING IN DEVELOPMENTAL BIOLOGY OF MEMBRANE TRANSPORT

描述(改编自申请人的描述)：本报告的目的 建议培训儿科医学博士和医学博士/博士内科科学家 在发展领域作为独立调查人员的成功职业生涯 生理学和细胞生物学，特别是当它与理解 膜运输的个体发育和调控。研究的三个优先事项 已经确定了培训：1)识别和表征运输 蛋白质及其与细胞生长相关的功能相互作用， 分化与动态平衡的维持；2)测定 遗传性和获得性精神障碍的发育和遗传学基础 膜转运；以及3)开发新的治疗策略(例如，基因 治疗)膜转运障碍。收录了两个临床病例 和具有研究兴趣和专业知识的基础科学教员 这些相关领域将提供基础研究培训经验。全 参加这一培训计划的考生将至少投入 花了三年时间研究训练。

DESCRIPTION (Adapted from applicant's description): The objective of this proposal is to train pediatric M.D. and M.D./Ph.D. physician-scientists for successful careers as independent investigators in the field of developmental physiology and cell biology, specifically as it relates to understanding the ontogeny and regulation of membrane transport. Three priorities for research training have been identified: 1) To identify and characterize transport proteins and their functional interactions as they relate to cell growth, differentiation and the maintenance of homeostasis; 2) To determine the developmental and genetic bases for inherited and acquired disorders of membrane transport; and 3) To develop new therapeutic strategies (e.g., gene therapy) for disorders of membrane transport. The inclusion of both clinical and basic science faculty preceptors with research interests and expertise in these related fields will provide a basic research training experience. All candidates for this training program will be expected to devote a minimum of three years to research training.