9th International Workshop on Developmental Nephrology

描述(由申请人提供)： 本申请是对将于2004年8月25日至27日在南澳大利亚州巴罗萨山谷举行的第九届发育肾病国际研讨会的部分支持申请。在过去的几十年里，随着儿科肾病的诞生，发育肾生理学的学科也随之发展起来。到1980年，世界上致力于这一领域的研究人员的数量已经增加到第一届发育肾生理学国际研讨会在纽约举行的地步。第一期讲习班的成功促成了随后每隔3年举办一次讲习班，每次讲习班都是结合国际儿科肾病学会(IPNA)三年一次的大会举行的。该研讨会的目的是全面分析发育性肾病的最新进展。肾脏发育的研究最初主要由儿科肾病学家负责，但最近肾脏疾病的细胞和分子生物学以及分子遗传学的爆炸性发展导致许多学科的研究人员将注意力集中在肾脏发育上。因此，讲习班将包括儿科肾病学、肾脏医学、生理学、细胞生物学、发育生物学、病理学、分子生物学和遗传学等学科的研究人员参加。第一天将讨论肾脏和胃肠道花纹在健康和疾病中的分子控制。第二天将集中在肾小球、小管和血管系统水平上的3D建筑模式。还将讨论正常上皮细胞分化的过程，包括建立肾小管运输的极性和个体发育，以及通过信号通路进行调节。最后一天将突出我们对终末分化缺陷和肾脏对损伤的反应的理解方面的新进展，重点是对发育程序的回顾。两个海报会议将提供介绍免费交流的机会。通过留出充足的问答时间，该计划旨在成为一个有利于交流与发育中的肾脏的生物学、病理生理学和遗传学有关的新知识、新技术和新概念的论坛。会议将在巴罗萨山谷度假村举行，这是进行这种互动的最佳地点，紧接着在南澳大利亚州阿德莱德举行第13届IPNA大会(2004年8月29日至9月2日)。

DESCRIPTION (provided by applicant): This application is a request for partial support for the 9th International Workshop on Developmental Nephrology, to be held in the Barossa Valley, South Australia (August 25-27, 2004). The discipline of developmental renal physiology evolved along with the birth of pediatric nephrology over the past several decades. By 1980, the number of investigators in the world dedicated to this field had increased to the point where the 1st International Workshop on Developmental Renal Physiology was held in New York. The success of this initial Workshop led to the organization of subsequent Workshops at 3-year intervals, each in conjunction with the triennial Congress of the International Pediatric Nephrology Association (IPNA). The aim of the Workshop is to provide a comprehensive analysis of the state-of-the-art of developmental nephrology. Whereas investigation of the developing kidney had initially been chiefly the province of pediatric nephrologists, the recent explosion in cell and molecular biology as well as the molecular genetics of renal disease has resulted in the recruitment of investigators from many disciplines to focus their attention on the developing kidney. Thus, the Workshop will include the participation of investigators in disciplines including pediatric nephrology, renal medicine, physiology, cell biology, developmental biology, pathology, molecular biology and genetics. The first day will address the molecular control of patterning in the kidney and GU tract in health and disease. The second day will focus on patterning for 3D architecture at the level of the glomerulus, tubules and vasculature. Processes involved in normal epithelial differentiation will also be discussed, including establishment of polarity and ontogeny of tubular transport, and regulation by signaling pathways. The final day will highlight new advances in our understanding of defects in terminal differentiation and the response of the kidney to injury, with an emphasis on recapitulation of developmental programs. Two poster sessions will provide an opportunity for presentation of free communications. By allowing ample time for questions and answers, the program is designed to serve as a forum conducive to the exchange of new knowledge, techniques, and concepts relating to the biology, pathophysiology, and genetics of the developing kidney. The meeting will be held at Barossa Valley Resort, an optimal venue for such interaction, immediately preceding the 13th IPNA Congress in Adelaide, South Australia (August 29-September 2, 2004).