Graduate Training in Developmental Biology

发育生物学研究生培训

• 批准号: 8854902
• 负责人: Michael Granato
• 金额: $ 32.76万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8854902
• 关键词: Developmental Biology; Training

 DESCRIPTION (provided by applicant): This is a new submission for a broad based predoctoral training program in developmental biology. The program takes advantage of the programmatic infrastructure established through a highly successful 15 year long training grant in developmental biology that expired in 2014. The proposed training program requests 12 trainee slots per year. Each year 6 trainees will be appointed for a duration of 2 years so that at any given time the training program will include 6 trainees in their first and 6 trainees in their second year of support (12 trainee slots/year). The proposed training program includes faculty from multiple schools and departments within the University and reflects a major and continuing expansion of developmental biology research and training. The new plan emphasizes laboratory research directed towards basic mechanisms of embryonic development using a diversity of vertebrate, invertebrate, and plant organisms. It fosters the application of modern genetic, genomic, cellular, molecular and high resolution imaging approaches to developmental studies. Research training areas include transcription and cell signaling mechanisms that control cell lineage determination, differentiation, migration, organogenesis, cellular senescence, morphogenesis, pattern formation, epigenetic regulation of developmental processes, and stem cell biology. Trainees are encouraged to explore clinical research areas including cancer and genetic diseases of development. In preparation for their research training, predoctoral students receive formal instruction in an established curriculum of study, including lecture courses in developmental biology and advanced seminars on genetic, cellular, and molecular approaches to developmental mechanisms and disease. Students will also participate in developmental biology journal clubs, a developmental biology seminar series that includes student invited speakers, research discussion groups on selected topics, and in annual scientific symposia. Trainees present their research findings at departmental seminars, local symposia and national conferences. Finally, the training program will provide trainees with dedicated a) semiannual Show and Tell research days where trainees will lecture other trainees about their project followed by a hands-on demonstration of research techniques employed by the trainee presenter, e.g. live cell imaging, b) a yearly retreat to present their work in a more formal settig that includes an eminent external speaker who will help evaluate this training program, c) crafting of an Individual Development Plan and its yearly review by the Directors, d) Professional development seminars, such as mini-writing classes tailored to graduate students, e) quarterly lunchtime discussion with a Penn faculty of the trainee's choice to ask questions about the faculty's field of research and/or to discuss general issues such as lab management or career path decisions, f) brief `job shadowing' internships in pharmaceutical, translational, or other settings to explore different aspects of working in the pharmaceutical/biotech sector.

 描述(由申请人提供)：这是一个新提交的基础广泛的发展生物学博士前培训计划。该方案利用了通过2014年到期的为期15年的发育生物学培训赠款非常成功地建立的方案基础设施。拟议的培训方案要求每年提供12个实习生名额。每年将任命6名实习生，任期为2年，以便在 在任何给定的时间，培训方案将包括6名第一年的受训人员和6名第二年支助的受训人员(12个受训人员/年)。拟议的培训计划包括来自该大学多个学院和系的教员，反映了发育生物学研究和培训的主要和持续扩展。新计划强调利用各种脊椎动物、无脊椎动物和植物有机体对胚胎发育的基本机制进行实验室研究。它促进了现代遗传、基因组、细胞、分子和高分辨率成像方法在发育研究中的应用。研究培训领域包括控制细胞谱系确定、分化、迁移、器官形成、细胞衰老、形态发生、模式形成、发育过程的表观遗传调控和干细胞生物学的转录和细胞信号机制。鼓励学员探索临床研究领域，包括癌症和发育中的遗传病。在为他们的研究培训做准备时，博士前学生在既定的学习课程中接受正式指导，包括发育生物学的讲座课程，以及关于发育机制和疾病的遗传、细胞和分子方法的高级研讨会。学生还将参加发育生物学期刊俱乐部，这是一个发育生物学研讨会系列，包括学生特邀演讲者，选定主题的研究讨论小组，以及年度科学研讨会。受训人员在部门研讨会、地方研讨会和全国会议上介绍他们的研究成果。最后，培训计划将为受训者提供专门的a)半年一次的展示和讲授研究日，受训者将在其中向其他受训者讲授他们的项目，然后由受训者实际演示研究技术，例如活细胞成像，b)年度静修，以在更正式的背景下介绍他们的工作，其中包括一位著名的外部演讲者，他将帮助评估该培训计划，c)起草个人发展计划并由董事进行年度审查，d)专业发展研讨会，如为研究生量身定做的迷你写作课程，E)与受训者选择的宾夕法尼亚大学教职员工每季度进行午餐讨论，询问有关教职员工研究领域的问题和/或讨论实验室管理或职业道路决定等一般问题，f)在制药、翻译或 其他环境，以探索制药/生物技术部门工作的不同方面。