LEARNING IN THE HUMAN MOTOR CORTEX

描述：(改编自《调查员摘要》)： 本研究旨在了解大脑皮层激活的动态变化。 这是内隐运动学习的基础。在当前的提案中，我们使用序列 内隐运动模型Nissen和Bullemer的反应时任务(SRTT) 学习和研究ITS期间皮质运动区的功能激活 使用模块化设计和事件相关功能磁共振成像的性能。具体目标 主要研究内容如下：(1)研究学习的神经基础 受试者指向不同空间目标集合的SRTT，(2)至 评估内隐学习障碍的功能相关性 在等长条件下发生，(3)确定 基于成绩的内隐学习 学习是通过改变刺激呈现的速度来操纵的，以及(4) 在学习过程中使用SRTT检查皮质运动区的激活 与事件相关的功能磁共振成像。为每个目标收集的数据将使我们能够 解决以下问题：(I)对运动行为的哪个方面进行编码 它的神经基础是什么？(Ii)本体感觉的作用是什么？ 内隐学习中的反馈，以及反馈的调节方式 功能激活告诉我们学习过程本身，(Iii)将 我们观察到的学习和表现之间的脱节也得到了反映 在运动区的不同激活中，对翻译很重要 将知识转化为行动；以及(Iv)学习在多大程度上反映在变化中 在皮质运动区之间激活的相对时间上。就像我们的 运动行为是基于内隐学习的，内隐学习是可能的 学习范例可以有益地用于运动康复 卒中。

DESCRIPTION: (Adapted from the Investigator's Abstract): The long-term goal of this research is to understand the dynamic changes in cortical activation which underlie implicit motor learning. In the current proposal we use the serial reaction time task (SRTT) of Nissen and Bullemer as a model of implicit motor learning and study functional activation in cortical motor areas during its performance using both blocked design and event-related fMRI. The specific aims are as follows: (1) To study the neural substrate of learning in a variant of the SRTT in which subjects point to different sets of spatial targets, (2) to evaluate the functional correlates of an impairment in implicit learning which occurs under isometric conditions, (3) to determine the neural substrate of performance-based implicit learning in conditions in which the expression of learning is manipulated by varying the rate of stimulus presentation, and (4) to examine activation in cortical motor areas during learning in the SRTT using event-related fMRI. The data collected for each of the aims will enable us to address the following issues: (i) Which aspect of the motor behavior is encoded and what is its neural substrate, (ii) What is the role of proprioceptive feedback in implicit learning, and does the way in which it modulates functional activation inform us about the learning process itself, (iii) Will the dissociation we have observed between learning and performance be reflected in the differential activation of motor areas important for the translation of knowledge into action, and (iv) to what extent is learning reflected in changes in the relative timing of activation among cortical motor areas. As much of our motor behavior is based on implicit learning it is possible that implicit learning paradigms could be used beneficially for motor rehabilitation in stroke.