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Neurophysiology of time production

时间产生的神经生理学

基本信息

批准号：
7380054
负责人：
JAMES ASHE
金额：
$ 3.03万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-15 至 2009-02-28
项目状态：
已结题

项目摘要

This research will be done primarily in Mexico at the Institute of Neural Biology, National University of Mexico in collaboration with Hugo Merchant-Nancy as an extension of NIH grant # 5R01-NS042778. Interval timing is a complex process that is not link exclusively to any sensory modality and that is involved in a broad spectrum of behaviors, ranging from object interception and collision avoidance to musical performance and speech. However, there is a remarkable lack of information regarding the neurophysiological basis of temporal processing. The goal of the work outlined in this proposal is to gain understanding of the neural basis of interval timing in 100 -1000 ms scale, and more specifically to investigate the role of the corticothalamic-basal ganglia circuit (CTBG) in this behavior. Although many pharmacological, lesion and imaging studies have implicated CTBG in temporal processing, the neural mechanisms of interval timing are still unknown. Our general thesis is that the production of time intervals depends on an internal clock whose neurophysiological mechanism is based on the distributed processing of information throughout the CTBG. In order to test these ideas, Rhesus monkeys will be trained in tasks that involve the production of single or multiple time intervals. The impulse activity of single cells will be recorded during task performance in two structures of the CTBG, namely, the supplementary motor area (SMA) and the putamen using a 7-microelectrode system. The data will be analyzed using uni-and multivariate statistical methods to correlate timing behavior and single cell and population activity. This will allow us to elucidate the role of CTBG components in temporal information processing, decipher the neural codes, and reveal the mechanism of the interval timing.

这项研究将主要在墨西哥国立大学神经生物学研究所进行墨西哥与 Hugo Merchant-Nancy 合作，作为 NIH 拨款 # 5R01-NS042778 的延伸。间隔计时是一个复杂的过程，并不专门与任何感觉方式相关，而且涉及广泛的行为，从物体拦截和避免碰撞到音乐表演和演讲。然而，关于该问题的信息明显缺乏时间处理的神经生理学基础。本提案中概述的工作目标是获得了解 100 -1000 毫秒范围内间隔计时的神经基础，更具体地说是研究皮质丘脑基底神经节回路（CTBG）在此行为中的作用。虽然很多药理学、病变和影像学研究表明 CTBG 参与时间处理、神经间隔计时的机制仍然未知。我们的一般论点是时间间隔的产生取决于内部时钟，其神经生理机制基于分布式处理整个 CTBG 中的信息。为了测试这些想法，恒河猴将接受以下任务的训练：涉及单个或多个时间间隔的产生。记录单个细胞的脉冲活动在执行任务时，CTBG 的两个结构，即辅助运动区 (SMA) 和使用 7 微电极系统的壳核。数据将使用单变量和多变量进行分析将计时行为与单细胞和群体活动相关联的统计方法。这将使我们能够阐明 CTBG 成分在时间信息处理中的作用，破译神经代码，以及揭示间隔计时的机制。