Neurophysiology of time production

时间产生的神经生理学

• 批准号: 7221262
• 负责人: JAMES ASHE
• 金额: $ 3.03万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7221262
• 关键词: Animal Model; Area; Basal Ganglia; Behavior; Behavioral; Biological Clocks; Biology; Cells; Code; Collaborations; Complex; Computer information processing; Data; Detection; Elements; Goals; Grant; Image; Institutes; Investigation; Lesion; Link; Macaca mulatta; Medial; Mexico; Microelectrodes; Modality; Motor; Motor Cortex; Motor output; Movement; Neurons; Performance; Population; Process; Production; Property; Purpose; Range; Reaction Time; Research; Role; Sensory; Signal Transduction; Speech; Statistical Methods; Stimulus; Structure; System; Task Performances; Techniques; Testing; Thalamic structure; Time; Training; United States National Institutes of Health; Universities; Work; base; combinatorial; design; frontal lobe; motor learning; neuromechanism; neurophysiology; parent grant; putamen; relating to nervous system; sequence learning; time interval

DESCRIPTION (provided by applicant): This research will be done primarily in Mexico at the Institute of Neural Biology, National University of Mexico in collaboration with Hugo Merchant-Nancy as an extension of NIH grant # 5R01-NS042778. Interval timing is a complex process that is not linked exclusively to any sensory modality and that is involved in a broad spectrum of behaviors, ranging from object interception and collision avoidance to musical performance and speech. However, there is a remarkable lack of information regarding the neurophysiological basis of temporal processing. The goal of the work outlined in this proposal is to gain understanding of the neural basis of interval timing in 100--1000 ms scale, and more specifically to investigate the role of the corticothalamic-basal ganglia circuit (CTBG) in this behavior. Although many pharmacological, lesion and imaging studies have implicated CTBG in temporal processing, the neural mechanisms of interval timing are still unknown. Our general thesis is that the production of time intervals depends on an internal clock whose neurophysiological mechanism is based on the distributed processing of information throughout the CTBG. In order to test these ideas, Rhesus monkeys will be trained in tasks that involve the production of single or multiple time intervals. The impulse activity of single cells will be recorded during task performance in 2 structures of the CTBG, namely, the supplementary motor area (SMA) and the putamen using a 7-microelectrode system. The data will be analyzed using uni-and multivariate statistical methods to correlate timing behavior and single cell and population activity. This will allow us to elucidate the role of CTBG components in temporal information processing, decipher the neural codes, and reveal the mechanism of the interval timing.

描述（由申请人提供）：本研究将主要在墨西哥墨西哥国立大学神经生物学研究所进行，与Hugo Merchant-Nancy合作，作为NIH拨款# 5R01-NS042778的延伸。间隔计时是一个复杂的过程，并不仅仅与任何感官形态有关，它涉及到广泛的行为，从拦截物体和避免碰撞到音乐表演和演讲。然而，关于时间加工的神经生理基础的信息明显缺乏。这项研究的目标是了解100- 1000毫秒间隔时间的神经基础，更具体地说，是研究皮质丘脑-基底神经节回路（CTBG）在这种行为中的作用。尽管许多药理学、病变和影像学研究表明CTBG与颞叶加工有关，但间隔时间的神经机制仍不清楚。我们的一般论点是，时间间隔的产生取决于内部时钟，其神经生理机制是基于整个CTBG信息的分布式处理。为了测试这些想法，恒河猴将接受训练，完成涉及产生单个或多个时间间隔的任务。使用7微电极系统记录CTBG中辅助运动区（SMA）和壳核两个结构在任务执行过程中单细胞的脉冲活动。数据将使用单变量和多变量统计方法进行分析，以将时序行为与单细胞和种群活动联系起来。这将有助于我们阐明CTBG成分在时间信息处理中的作用，破译神经编码，揭示间隔时间的机制。