Corticostriatal Influences on Neostriatal Processing

皮质纹状体对新纹状体加工的影响

• 批准号: 6545452
• 负责人: Kevin Douglas Alloway
• 金额: $ 29.34万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6545452
• 关键词: brain electrical activity; brain mapping; cats; caudate nucleus; central neural pathway /tract; cerebral cortex; corpus striatum; electrophysiology; exploratory behavior; histology; laboratory rat; microelectrodes; neural information processing; neuronal transport; pons; putamen; sensorimotor system; somesthesis; somesthetic sensory cortex; stereotaxic techniques; stimulus /response; vibrissae

DESCRIPTION (provided by applicant): The neostriatum and related parts of the basal ganglia contain functional channels that separately process prefrontal, limbic, oculomotor, and sensorimotor information received from the cerebral cortex. Although the specific cortical areas that activate each functional channel are different, each channel contains the same basic input-output pattern of connections. By using cutaneous stimuli to activate corticostriatal projections from somatosensory cortex, we can characterize the pattern recognition properties of neostriatal neurons and determine how neural activity in the sensorimotor channel is coordinated during sensory stimulation. Hence, this paradigm presents a unique opportunity for understanding the rules that govern the dynamic operation of corticostriatal circuits across all functional channels because there are no accepted methods for directly activating limbic or prefrontal channels in a controlled, naturalistic manner. The anatomic and physiologic properties of the neostriatum represent a significant issue in contemporary neuroscience because this brain region has been implicated in Parkinson's disease, Huntington's chorea, Tourette's syndrome, and schizophrenia. In this project we will use anterograde tracing methods to test the hypothesis that corresponding representations in the primary and secondary somatosensory cortical areas send convergent projections to the neostriatum. We will also use retrograde tracing techniques to verify previous results indicating that corticostriatal projections from somatosensory cortex have an anisostropic organization. We will also compare corticostriatal and corticopontine projections to determine if the corticopontine projections follow the same principles of organization that have been identified in the corticostriatal system (ie. Principles of Cortical Proximity, Somatotopic Homology, and Behavioral Cooperativity). Finally, we will record neuronal activity in multiple parts of the cerebral cortex and neostriatum so that we may analyze neuronal interactions between the cortex and neostriatum. These physiology studies will determine whether a primary function of neostriatal neurons is to detect synchronized activity among functionally-related cortical areas.

描述(申请人提供)：新纹状体和基底节的相关部分包含功能通道，分别处理从大脑皮层接收到的前额叶、边缘、动眼和感觉运动信息。尽管激活每个功能通道的特定皮质区域不同，但每个通道包含相同的基本输入输出连接模式。通过使用皮肤刺激激活来自躯体感觉皮质的皮质纹状体投射，我们可以表征新纹状体神经元的模式识别特性，并确定在感觉刺激过程中感觉运动通道中的神经活动是如何协调的。因此，这一范式为理解支配所有功能通道的皮质纹状体回路动态运行的规则提供了一个独特的机会，因为还没有公认的方法以受控的、自然的方式直接激活边缘或前额叶通道。 新纹状体的解剖和生理特性代表了当代神经科学中的一个重要问题，因为这个大脑区域与帕金森氏症、亨廷顿舞蹈症、抽动症和精神分裂症有关。在这个项目中，我们将使用顺行追踪方法来检验这样的假设，即初级和次级躯体感觉皮质区的相应表征向新纹状体发送会聚投射。我们还将使用逆行追踪技术来验证先前的结果，该结果表明来自躯体感觉皮质的皮质纹状体投射具有各向异性组织。我们还将比较皮质纹状体和桥脑皮质的投射，以确定桥脑投射是否遵循已在皮质纹状体系统中确定的相同的组织原则(即。皮质邻近原则、体位同源性和行为协作性)。最后，我们将记录大脑皮层和新纹状体多个部分的神经元活动，以便我们可以分析皮质和新纹状体之间的神经元相互作用。这些生理学研究将确定新纹状体神经元的主要功能是否是检测功能相关的皮质区域之间的同步活动。