Integrated magnetic resonance and infrared imaging system for studying neural act

用于研究神经行为的集成磁共振和红外成像系统

• 批准号: 7387636
• 负责人: Kevin Douglas Alloway
• 金额: $ 16.31万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-09 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7387636
• 关键词: Algorithms; Brain; Brain Mapping; Brain imaging; Clip; Compatible; Computer Simulation; Data; Development; Elements; Frequencies; Functional Magnetic Resonance Imaging; Hemoglobin; Image; Invasive; Laboratory Rat; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Measures; Neuronal Plasticity; Optical Image Reconstruction; Optical Instrument; Optics; Pattern; Peripheral; Phase; Placement; Protocols documentation; Range; Rattus; Relative (related person); Resolution; Rodent; Rodent Model; Sensory; Signal Transduction; Somatosensory Cortex; Source; Stimulus; System; Techniques; Testing; Veins; Vibrissae; Water; absorption; capillary bed; data acquisition; design; detector; diffuse optical tomography; image reconstruction; improved; optical imaging; relating to nervous system; research study; response; size; somatosensory; validation studies

DESCRIPTION (provided by applicant): The aim of this proposal is to perform non-invasive, simultaneous functional magnetic resonance imaging (fMRI) and diffuse optical tomography (DOT) in rodent models of neural plasticity. The technique will develop an integrated MRI/optical probe, designed specifically for imaging the rat cortex. This probe will enable dual-wavelength multiple source/detector nearinfrared DOT and phased-array fMRI. This system will be used to measure the plasticity of neural responses at high spatial and temporal resolution using well-characterized whisker-clipping paradigms. We hypothesize that fMRI and DOT will detect spatial and temporal differences in stimulus-induced neural responses evoked in control and sensory-deprived (selective whisker clipping) rats. Finally, we will add a third wavelength to the DOT system to elucidate a fundamental question in optical imaging, namely the extent of the large-vessel contribution to the optical signal in brain activation. We will test the hypothesis that changes in the absorption coefficient in large veins do not contribute significantly to changes in the optical signal, and provide an accurate estimation of the relative signal changes from the capillary bed and small vessels.

描述（由申请人提供）：本提案的目的是在啮齿动物神经可塑性模型中进行非侵入性，同步功能磁共振成像（fMRI）和弥漫性光学断层扫描（DOT）。该技术将开发一种集成的MRI/光学探针，专门用于对大鼠皮层进行成像。该探头将实现双波长多源/探测器近红外DOT和相控阵功能磁共振成像。该系统将用于测量神经反应的可塑性，在高空间和时间分辨率使用表征良好的晶须修剪范式。我们假设fMRI和DOT将检测到控制组和感觉剥夺组（选择性剃须）大鼠刺激诱导的神经反应的空间和时间差异。最后，我们将在DOT系统中添加第三个波长，以阐明光学成像中的一个基本问题，即大血管对脑激活光信号的贡献程度。我们将检验大静脉吸收系数的变化对光信号的变化没有显著贡献的假设，并提供来自毛细管床和小血管的相对信号变化的准确估计。