Effects of parvalbumin up-regulation on Ca2+ handling and contractile properties in skeletal muscle from aged mice

小白蛋白上调对老年小鼠骨骼肌 Ca2 处理和收缩特性的影响

• 批准号: nhmrc : 520186
• 负责人: Dr Kate Murphy
• 金额: $ 19.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-parvalbumin-up-aged-mice/115774
• 关键词: Effects; parvalbumin; up; regulation; Ca2+

Ageing is accompanied by a loss of muscle function that may be due to an ageing-related impairment of calcium regulation. This project aims to improve calcium regulation in muscles of aged animals by enhancing the calcium buffering capacity via gene transfer. Whether this improves muscle function and muscle regeneration following injury in the aged will be assessed. Information from this project could lead to development of novel strategies to combat the loss of muscle function with ageing.

衰老伴随着肌肉功能的丧失，这可能是由于与衰老相关的钙调节受损所致。本项目旨在通过基因转移来提高老龄动物肌肉的钙缓冲能力，从而改善肌肉中的钙调节。这是否会改善老年人受伤后的肌肉功能和肌肉再生将得到评估。来自该项目的信息可能会导致开发新的战略，以对抗随着年龄增长而丧失的肌肉功能。