Core--Neuropathology of Parkinson's disease and related Lewy body disorders

该核心将用于收集、存储和分析以下患者的脑组织：(1)患有相关神经系统疾病的患者，包括帕金森病（PD）和路易体痴呆（DLB）；(2)其他神经系统疾病患者，包括阿尔茨海默病以及其他运动障碍；(3)无神经系统疾病证据的患者；(4)寻求建立PD、DLB和其他突触核蛋白相关神经退行性疾病模型的转基因小鼠。核心的第一个主要组成部分将处理人体组织。在委员会认证的神经病理学家Matthew Frosch博士的指导下，核心人员将在尸检时收集材料，并按照中心各个项目中考虑的生化、组织学和结构研究的方式准备和存储样本。然后，这些病例还将以标准化的方式进行详细的神经病理学分析，以确保临床诊断的准确性和对每个病例具体病理的理解。所有材料将以匿名方式存储。核心的第二个组成部分将处理动物组织的收集，准备和组织学分析，特别是来自中心其他地方开发的转基因小鼠的大脑。在Cynthia Lemere博士的指导下，这部分核心将为中心的其他项目提供经验丰富的组织学服务。用于分析这些动物的组织学方法将与用于诊断上述人类材料的方法平行。

This core will serve to collect, store and analyze brain tissue from: (l) patients with relevant neurologic diseases, including Parkinson disease (PD) and dementia with Lewy bodies (DLB); (2) patients with other neurologic disorders, including Alzheimer disease as well as other movement disorders; (3) patients without evidence of neurologic disease; and (4) transgenic mice which seek to model PD, DLB and other synuclein-associated neurodegenerative disorders. The first major component of the core will deal with human tissues. The core -- under the direction of a board-certified neuropathologist, Dr. Matthew Frosch -- will collect material at the time autopsy, and prepare and store samples in a manner compatible with biochemical, histologic and structural studies as considered in the various projects of the Center. The cases will then also be subjected to a detailed neuropathologic analysis, in a standardized manner, in order to ensure the accuracy of clinical diagnosis and the understanding of the pathology specific to each case. All material will be stored in an anonymized manner. The second component of the core will deal with the collection, preparation and histologic analysis of animal tissue, specifically brains from transgenic mice developed elsewhere in the Center. This portion of the core, under the direction of Dr. Cynthia Lemere, will provide experienced histologic services to the other projects of the Center. The histologic methods used in the analysis of these animals will parallel those used in the diagnosis of the human material considered above.