Core--Neuropathology of Parkinson's disease and related Lewy body disorders

核心--帕金森病及相关路易体疾病的神经病理学

• 批准号: 6499889
• 负责人: MATTHEW P FROSCH
• 金额: $ 24.81万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6499889
• 关键词: Lewy body; Parkinson's disease; biomedical facility; histology; human tissue; laboratory mouse; neuropathology; postmortem; tissue resource /registry

This core will serve to collect, store and analyze brain tissue from: (l) patients with relevant neurologic diseases, including Parkinson disease (PD) and dementia with Lewy bodies (DLB); (2) patients with other neurologic disorders, including Alzheimer disease as well as other movement disorders; (3) patients without evidence of neurologic disease; and (4) transgenic mice which seek to model PD, DLB and other synuclein-associated neurodegenerative disorders. The first major component of the core will deal with human tissues. The core -- under the direction of a board-certified neuropathologist, Dr. Matthew Frosch -- will collect material at the time autopsy, and prepare and store samples in a manner compatible with biochemical, histologic and structural studies as considered in the various projects of the Center. The cases will then also be subjected to a detailed neuropathologic analysis, in a standardized manner, in order to ensure the accuracy of clinical diagnosis and the understanding of the pathology specific to each case. All material will be stored in an anonymized manner. The second component of the core will deal with the collection, preparation and histologic analysis of animal tissue, specifically brains from transgenic mice developed elsewhere in the Center. This portion of the core, under the direction of Dr. Cynthia Lemere, will provide experienced histologic services to the other projects of the Center. The histologic methods used in the analysis of these animals will parallel those used in the diagnosis of the human material considered above.

该中心将用于收集、存储和分析来自以下人群的脑组织：(1)帕金森氏病(PD)和路易体痴呆(DLB)等相关神经系统疾病的患者；(2)其他神经系统疾病，包括阿尔茨海默病和其他运动障碍的患者；(3)没有神经系统疾病证据的患者；以及(4)试图建立帕金森病、DLB和其他突触核蛋白相关神经退行性疾病模型的转基因小鼠。核心的第一个主要组成部分将处理人体组织。在委员会认证的神经病理学家Matthew Frosch博士的指导下，该中心将在尸检时收集材料，并以与中心各种项目中考虑的生化、组织学和结构研究相一致的方式准备和存储样本。然后，还将以标准化的方式对这些病例进行详细的神经病理分析，以确保临床诊断的准确性和对每个病例的具体病理的了解。所有材料将以匿名方式存储。核心的第二部分将处理动物组织的收集、准备和组织分析，特别是该中心其他地方培育的转基因小鼠的大脑。在辛西娅·勒梅尔博士的指导下，该中心的这一部分将为中心的其他项目提供经验丰富的组织学服务。用于分析这些动物的组织学方法将与用于上述人类材料诊断的方法类似。