Core D - Neuropathology Core

核心 D - 神经病理学核心

• 批准号: 8676353
• 负责人: MATTHEW P FROSCH
• 金额: $ 22.85万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676353
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Animal Model; Attention; Authorization documentation; Autopsy; Belief; Brain; Clinical; Clinical Research; Clinical assessments; Collaborations; Collection; Commit; Communication; Communities; Complement; DNA; Data; Data Storage and Retrieval; Deposition; Diagnosis; Diagnostic; Disease; Drug or chemical Tissue Distribution; Education; Educational Activities; Educational process of instructing; Environment; Epidemiologic Studies; Evaluation; Event; Family; Focus Groups; Freezing; Funding; Goals; Health Professional; Histologic; Histopathology; Human; Image; In Vitro; Individual; Massachusetts; Methods; Microscopy; Mission; Neurodegenerative Disorders; Neurofibrillary Tangles; Neurologist; Nurses' Health Study; Pathology; Performance; Philosophy; Plasma; Process; RNA; Reporting; Research; Research Personnel; Research Support; Resolution; Role; Sampling; Services; Staging; Tissue Banks; Tissue Donations; Tissue Sample; Tissues; Tissues Repository Operations; Training; United States National Institutes of Health; Validation; Withdrawal; Work; abstracting; base; brain tissue; career development; data sharing; digital; end stage disease; imaging modality; innovation; neuropathology; novel; novel strategies; outreach; prevent; programs; tissue fixing; tissue resource; tomography; white matter

NEUROPATHOLOGY CORE PROJECT SUMMARY/ABSTRACT The underlying philosophy of the Neuropathology Core is the belief that validation of diagnosis is critical to clinical research into neurodegenerative diseases and that tissue- and other biospecimen-based studies are a vital complement to in vitro studies of the biologic processes underlying these diseases. From these two pillars to the clinical and scientific community, the Core is able to make a contribution to the amelioration of suffering associated with AD and related disorders. The Core therefore supports the overall mission of the MADRC through the collection, characterization, storage and distribution of brain tissue and other biospecimens (CSF, plasma, DNA, RNA, etc) from subjects who have been well-characterized clinically. Samples from the Core have contributed to significant advances in our understanding of the biologic processes that characterize neurodegenerative diseases, both at early and later stages. The Core will serve to catalyze research into AD through collection, characterization and distribution of samples to individual investigators, larger consortia and collaborative groups and through data sharing with NACC (Aims 1-4). There are components of the Core's activities which are innovative, focused on developing novel tissue handling methods for high resolution microscopy which is important for understanding of early events in AD, on developing novel methods for imaging sharing and analysis and on harnessing opportunities provided by large epidemiologic studies to gather samples from control and early stage subjects (Aims 5-7). Finally, there is an educational component of the Core: training neuropathologists to be expert in diagnosis of neurodegenerative diseases and in the operations of tissue repositories in support of research; and teaching other health professionals about the importance of autopsy and tissue donation for research (Aims 8 & 9). The Core is integrated into all Center activities with active interactions with Administrative, Clinical and Outreach Cores regarding autopsy permission and education, with the Data Core regarding data storage and communication with NACC, and with the projects. Projects 2 and 3 both depend on neuropathological samples from the Core, and our routine evaluation of brains includes attention to the white matter, which complements Project 1's Connectome studies. We also support the local research community and national initiatives, with 309 requests for materials over the past 4 years (including >3600 frozen tissue samples and >17,000 unstained section). Thus, there is an ever-increasing role for the activities of the Core in contributing to research in AD and other dementing illnesses.

神经病理学核心项目总结/摘要 神经病理学核心的基本理念是相信诊断的有效性对于 神经退行性疾病的临床研究，以及基于组织和其他生物学的研究是一个 这是对这些疾病背后的生物过程的体外研究的重要补充。从这两个支柱 对于临床和科学界来说，核心能够为改善痛苦做出贡献。 与AD和相关疾病相关。因此，核心支持MADRC的总体使命 通过脑组织和其它生物样本（CSF， 血浆、DNA、RNA等）。 来自地核的样本有助于我们对生物过程的理解取得重大进展 神经退行性疾病的早期和晚期特征。 该核心将通过收集、表征和分发样本来促进AD研究 通过与NACC共享数据， 第1-4段）。核心组织的一些活动是创新的，重点是开发新型组织 高分辨率显微镜的处理方法，这对于理解AD的早期事件非常重要， 开发成像共享和分析的新方法以及利用大型公司提供的机会 流行病学研究，从对照和早期受试者中收集样本（目标5-7）。最后，有一个 核心的教育部分：培训神经病理学家成为神经退行性疾病诊断专家 组织库的运作以支持研究;以及教授其他健康知识。 向专业人员介绍尸检和组织捐赠对研究的重要性（目标8和9）。核心是 与行政、临床和外展核心积极互动，融入所有中心活动 关于尸检许可和教育，数据核心关于数据存储和通信 与NACC和项目合作。项目2和项目3都依赖于来自核心的神经病理学样本， 我们对大脑的常规评估包括对白色物质的关注，这是对项目1的补充 Connectome研究。我们还支持当地研究界和国家倡议，有309个请求 过去4年的材料（包括>3600份冷冻组织样本和> 17，000份未染色切片）。 因此，该中心的活动在促进反倾销和其他领域的研究方面发挥着越来越大的作用。 精神错乱的疾病