CHEMOKINE RECEPTOR EXPRESSION IN BRAIN OF MACAQUES W/ SIV ENCEPHALITIS

尽管HIV神经侵袭、神经元损伤和 HIV-1相关性痴呆综合征（ADC）的后续发展 尚未完全了解，单核细胞/巨噬细胞之间的相关性 脑浸润和神经系统疾病的存在， 趋化因子和趋化因子受体可能发挥的许多潜在作用 在HIV神经发病机制中，我们试图描述它们的模式， 在SIV感染的恒河猴HIV模型中的表达 我们以前证明了脑炎的表达升高， 猕猴脑内趋化因子MIP-1`、MIP-1、RANTES和IP-10 在这项研究中，我们证明， 相应的趋化因子受体CCR 3、CCR 5、CXCR 3以及CXCR 4是 在这些相同组织中的血管周围浸润中表达， 此外，我们还在大细胞亚群中检测到了CCR 3、CCR 5和CXCR 4。 海马和新皮质锥体神经元和胶质细胞 正常和脑炎c B雨这些发现表明， 多种趋化因子及其受体有助于单核细胞和 SIV脑炎中淋巴细胞向脑的募集此外， 已知的HIV/SIV共受体在神经元上的表达表明， HIV或SIV可以直接与这些病毒相互作用的可能机制 细胞，破坏其正常生理功能， ADC出版物Westmoreland SV，Rottman JB， 威廉姆斯KC，Lackner AA，Sasseville VG趋化因子受体表达 对SIV猕猴脑内驻留细胞和炎性细胞的影响 脑炎美国病理学杂志，152：659-665，1998

Although the mechanisms of HIV neuroinvasion, neuronal injury, and subsequent development of HIV-1-associated AIDS dementia complex (ADC) are not fully understood, a correlation between monocyte/macrophage infiltrates in the brain and neurologic disease exists In light of the many potential roles that chemokines and chemokine receptors may play in HIV neuropathogenesis, we sought to describe their pattern of expression in the SIV-infected rhesus macaque model of HIV encephalitis We previously demonstrated elevated expression of the chemokines MIP-1`, MIP-1 , RANTES, and IP-10 in brain of macaque monkeys with SIV encephalitis In this study, we demonstrate that the corresponding chemokine receptors CCR3, CCR5, CXCR3 and also CXCR4 are expressed in perivascular infiltrates in these same tissues In addition, we detected CCR3, CCR5, and CXCR4 on subpopulations of large hippocampal and neocortical pyramidal neurons and on glial cells in both normal and encephaliti c b rain These findings suggest that multiple chemokines and their receptors contribute to monocyte and lymphocyte recruitment to the brain in SIV encephalitis Furthermore, the expression of known HIV/SIV coreceptors on neurons suggests a possible mechanism whereby HIV or SIV can directly interact with these cells, disrupting their normal physiologic function and contributing to the pathogenesis of ADC Publications Westmoreland SV, Rottman JB, Williams KC, Lackner AA, Sasseville VG Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with SIV encephalitis Am J Pathol, 152:659-665, 1998