LEUKOCYTE TRAFFICKING IN SIV INFECTED RHESUS MONKEYS

感染 SIV 的恒河猴中的白细胞贩运

• 批准号: 6591341
• 负责人: VITO G SASSEVILLE
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6591341
• 关键词: AIDS; Mammalia; animal tissue; communicable diseases; immunology; inflammation; lymphatic system; skin; virus

In terminal SIV infection in macaques, lentivirus-infected leukocytes are numerous in SIV-specific infiltrates yet are rarely detected at inflammatory sites associated with opportunistic infections such as mycobacteriosis, SV40, and toxoplasmosis or in complete Freund's adjuvant (CFA)-induced skin granulomas This refutes the theory that opportunistic infections during HIV/SIV infection serve as a stimulus for the recruitment of lentivirus-infected cells However, during acute SIV-infection we have observed occasional animals with SIV-positive leukocytes associated with Pneumonyssus- and CFA-induced granulomas We have also described virus-positive cells in the cellular infiltrates associated with pulmonary granulomas induced by tetrathyridia of Mesocestoides in a pigtailed macaque (Macaca nemestrina) during acute SIV infection Our hypothesis is that SIV-infected leukocytes are able to traffic to inflammatory sites early in infection, but lose this ability late in dise ase

在猕猴中的SIV末端感染中，感染了慢病毒 白细胞在SIV特异性浸润中很多 在与机会主义相关的炎症部位检测到 诸如分枝杆菌，SV40和弓形虫病或IN等感染 完成Freund的佐剂（CFA）诱导的皮肤颗粒瘤 艾滋病毒/SIV感染期间机会主义感染的理论 充当刺激性慢病毒感染细胞的刺激 但是，在急性SIV感染期间，我们偶尔观察到 具有SIV阳性白细胞的动物与肺炎和 CFA诱导的肉芽瘤我们还描述了病毒阳性细胞 与肺肉芽肿相关的细胞浸润 通过蛋化猕猴的中胃苦植酸酯的四胆碱（Macaca 内尔斯特那（Nemestrina））在急性SIV感染期间我们的假设是 SIV感染的白细胞能够访问炎症部位 在感染的早期，但在Dise ASE中失去了这种能力