LEUKOCYTE TRAFFICKING IN SIV INFECTED RHESUS MONKEYS

感染 SIV 的恒河猴中的白细胞贩运

• 批准号: 6453787
• 负责人: VITO G SASSEVILLE
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6453787
• 关键词: AIDS; Mammalia; animal tissue; communicable diseases; immunology; inflammation; lymphatic system; skin; virus

In terminal SIV infection in macaques, lentivirus-infected leukocytes are numerous in SIV-specific infiltrates yet are rarely detected at inflammatory sites associated with opportunistic infections such as mycobacteriosis, SV40, and toxoplasmosis or in complete Freund's adjuvant (CFA)-induced skin granulomas This refutes the theory that opportunistic infections during HIV/SIV infection serve as a stimulus for the recruitment of lentivirus-infected cells However, during acute SIV-infection we have observed occasional animals with SIV-positive leukocytes associated with Pneumonyssus- and CFA-induced granulomas We have also described virus-positive cells in the cellular infiltrates associated with pulmonary granulomas induced by tetrathyridia of Mesocestoides in a pigtailed macaque (Macaca nemestrina) during acute SIV infection Our hypothesis is that SIV-infected leukocytes are able to traffic to inflammatory sites early in infection, but lose this ability late in dise ase

在猕猴的SIV感染末期，慢病毒感染 白细胞在SIV特异性浸润中大量存在， 在与机会性炎症相关的炎症部位检测到 感染，如分枝杆菌病、SV 40和弓形虫病，或 完全弗氏佐剂（CFA）诱导的皮肤肉芽肿 HIV/SIV感染过程中的机会性感染 作为慢病毒感染细胞募集的刺激物 然而，在急性SIV感染期间，我们观察到偶尔 SIV阳性白细胞与刺胞菌相关的动物， CFA诱导的肉芽肿我们还描述了在 与肺肉芽肿相关的细胞浸润诱导 由中鲸类的四足类在一个马尾猕猴（猕猴 nemestrina）在急性SIV感染期间，我们的假设是， SIV感染的白细胞能够运输到炎症部位 在感染早期，但在疾病晚期失去这种能力