STRUCTURE OF SUP35 FIBERS

SUP35 纤维的结构

• 批准号: 6444677
• 负责人: SUSAN LINDQUIST
• 金额: $ 29.31万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444677
• 关键词: aging; biomedical resource; genetics; growth /development; male; nervous system; plants

Prions have a new type of inheritance mi which altered phenotypes am based on the inheritance of proteins with self-perpetuating altered conformational states, rather than the inheritance of altered nucleic acids. The Sup35 protein from yeast is normally involved in translation termination. However, under certain conditions it behaves like a prion and forms long fibers. Ile STEM was used to determine the mass/length of different forms of fibers and their intermediates in formation.

Prion有一种新的遗传方式，它改变了表型 AM基于具有自我永续改变的蛋白质的遗传 构象状态，而不是改变的核的遗传 酸。酵母中的Sup35蛋白通常参与 翻译终止。然而，在某些条件下，它的行为 像普里恩一样，形成长长的纤维。Ile STEM用于确定 不同形式的纤维及其中间体的质量/长度 编队。