LUTEIN SUPPLEMENT EFFECT ON MACULAR PIGMENT DENSITY
补充叶黄素对黄斑色素密度的影响
基本信息
- 批准号:6448514
- 负责人:
- 金额:$ 7.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-04-01 至 2002-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
There is observational evidence, supported on theoretical grounds, for an inverse correlation between the amount of macular pigment (MP) in an individual's retina and the risk of acquiring age-related macular degeneration (AMD) Preliminary results from a small number of human subjects have shown that dietary supplementation with either lutein or zeaxanthin, which constitute the MP, can significantly increase the subjects' MP density. These results, if corroborated for the population at large, would provide relevant and subjects' MP density. These results, if corroborated for the population at large, would provide relevant and important information for the design of a clinical intervention study. Such a study would determine the efficacy of these two carotenoids in preventing the onset of the devastating, and as yet incurable, disease, AMD. Specific aim 1 of the proposed study is to investigate the effects of lutein supplementation, at different dosages, of lutein concentration in the blood serum and on the density of MP in 120 healthy human subjects. (Lutein is commercially available as a supplement; zeaxanthin is not.) It is our hypothesis that there will be a dose-dependent rate of accumulation of lutein within the macula. The results of the study will provide necessary information for determining the appropriate dose needed to produce an acceptable level of MP density within a given time-frame. The study will also quantify differences in response to supplementation among subjects, and will seek causes. In addition, the influence of a subject's age and gender will be determined. MP density in each subject will be measured frequently throughout the supplementation period by heterochromatic flicker photometry. The concentration of lutein in the subjects' serum will be measured regularly by high performance liquid chromatography MP density using the anticipated pool of 120 subjects in specific aim 1. AMD has been shown to be more prevalent in females compared with males, and in subjects with lighter irises. Specific aim 3 is to determine whether metabolites of lutein observed in the serum are accumulated in the retina and/or whether specific metabolites are formed in the retina. Liquid chromatography/mass spectroscopy (LC/MS) will be used to quantify the accumulation of oxidized lutein metabolites in the serum of the 120 subjects in specific aim 1, the subsequent elimination of the metabolites from the serum, as well as to aid in the identify of the metabolites. Finally, 30 donor eyes will be analyzed by LC/MS to determine which, if any, of the metabolites accumulates, or is formed, in the retina.
有理论支持的观察证据表明,个体视网膜中黄斑色素(MP)的数量与获得年龄相关性黄斑变性(AMD)的风险之间存在负相关关系。来自少数人类受试者的初步结果表明,膳食中补充叶黄素或玉米黄质(它们构成MP)可以显著增加受试者的MP密度。这些结果,如果在整个人群中得到证实,将提供相关的和受试者的MP密度。这些结果,如果在大多数人群中得到证实,将为临床干预研究的设计提供相关和重要的信息。这样一项研究将确定这两种类胡萝卜素在预防破坏性的、迄今无法治愈的黄斑变性疾病发病方面的功效。本研究的具体目的1是研究在120名健康受试者中,以不同剂量补充叶黄素对血清中叶黄素浓度和MP密度的影响。(叶黄素可以作为补充剂在市场上买到,玉米黄质则不行。)我们的假设是黄斑内叶黄素的积累速率与剂量有关。研究结果将提供必要的信息,以确定在给定时间范围内产生可接受的MP密度水平所需的适当剂量。该研究还将量化受试者对补充剂的反应差异,并寻找原因。此外,还将确定受试者的年龄和性别的影响。在整个补充期间,将通过异色闪烁光度法频繁测量每个受试者的MP密度。受试者血清中叶黄素的浓度将通过高效液相色谱MP密度定期测量,使用特定目的1的120名受试者的预期池。与男性相比,黄斑变性在女性中更为普遍,并且在虹膜较浅的受试者中更为普遍。特异性目的3是确定血清中观察到的叶黄素代谢物是否在视网膜中积累和/或是否在视网膜中形成特异性代谢物。液相色谱/质谱(LC/MS)将用于量化120名受试者血清中氧化叶黄素代谢物的积累,具体目的1,随后从血清中消除代谢物,以及帮助鉴定代谢物。最后,30只供体眼睛将通过LC/MS进行分析,以确定哪些代谢物(如果有的话)会在视网膜中积累或形成。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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JOHN T LANDRUM其他文献
JOHN T LANDRUM的其他文献
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{{ truncateString('JOHN T LANDRUM', 18)}}的其他基金
LUTEIN SUPPLEMENT EFFECT ON MACULAR PIGMENT DENSITY
补充叶黄素对黄斑色素密度的影响
- 批准号:
6584169 - 财政年份:2002
- 资助金额:
$ 7.38万 - 项目类别:
LUTEIN SUPPLEMENT EFFECT ON MACULAR PIGMENT DENSITY
补充叶黄素对黄斑色素密度的影响
- 批准号:
6579924 - 财政年份:2002
- 资助金额:
$ 7.38万 - 项目类别:
LUTEIN SUPPLEMENT EFFECT ON MACULAR PIGMENT DENSITY
补充叶黄素对黄斑色素密度的影响
- 批准号:
6656518 - 财政年份:2002
- 资助金额:
$ 7.38万 - 项目类别:
LUTEIN SUPPLEMENT EFFECT ON MACULAR PIGMENT DENSITY
补充叶黄素对黄斑色素密度的影响
- 批准号:
6301705 - 财政年份:2000
- 资助金额:
$ 7.38万 - 项目类别:
PROTECTION BY CAROTENOIDS AGAINST MACULAR DEGENERATION
类胡萝卜素预防黄斑变性
- 批准号:
6107306 - 财政年份:1999
- 资助金额:
$ 7.38万 - 项目类别:
PROTECTION BY CAROTENOIDS AGAINST MACULAR DEGENERATION
类胡萝卜素预防黄斑变性
- 批准号:
6217821 - 财政年份:1999
- 资助金额:
$ 7.38万 - 项目类别:
PROTECTION BY CAROTENOIDS AGAINST MACULAR DEGENERATION
类胡萝卜素预防黄斑变性
- 批准号:
6271662 - 财政年份:1998
- 资助金额:
$ 7.38万 - 项目类别:
PROTECTION BY CAROTENOIDS AGAINST MACULAR DEGENERATION
类胡萝卜素预防黄斑变性
- 批准号:
6240233 - 财政年份:1997
- 资助金额:
$ 7.38万 - 项目类别:
PROTECTION BY CAROTENOIDS AGAINST MACULAR DEGENERATION
类胡萝卜素预防黄斑变性
- 批准号:
5211858 - 财政年份:
- 资助金额:
$ 7.38万 - 项目类别:
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