Advanced Multi-channel Recording Electrodes

先进的多通道记录电极

• 批准号: 6444155
• 负责人: NADER M KALKHORAN
• 金额: $ 11.5万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444155
• 关键词: biomaterial compatibility; biomaterial evaluation; biomedical equipment development; biotechnology; ceramics; electrochemistry; electrodes; electronic recording system; histology; immunocytochemistry; implant; laboratory rat; medical implant science; nanotechnology; nervous system prosthesis; silicon; surface coating

DESCRIPTION (provided by applicant): The overall objective of this program is to use nanostructured porous silicon coatings to enhance the biocompatibility of ceramic-based multi-site neural recording electrode (CBMSE) arrays.Collaborating with K. Moxon of Drexel University, we have already fabricated CBMSE arrays that can chronically record multiple single neuron activity for up to three weeks. However, in order to use these electrodes for long-term studies or as neural interface components of neural prosthetic devices, recordings will have to be maintained for months or even years. We propose to use the porous silicon nanostructures as a scaffold system, attached to the CBMSE array. We anticipate the porous Si scaffold system will a) carry neurotrophic factors to the insertion region of the electrode to minimize neural damage, and b) promote neural growth at the electrode/tissue interface for better contact of the recording sites on the CBMSE array with neurons. To demonstrate the feasibility of this goal in Phase I, Spire, in collaboration with Drexel University, will fabricate single element porous Si-coated CBMSE-based electrodes that will be implanted into a group of laboratory rats and the effect on neural tissue will be evaluated at different time intervals. The neural tissue will be evaluated using histology methods to look for neural damage near the site of implantation and study the growth of neurons into the porous silicon coated electrodes. Dr. M. Frosch, M.D. of Massachusetts General Hospital will assist in interpretation of these histologic findings. In Phase II, upon optimizing the process parameters for producing hybrid porous silicon-CBMSE electrodes, we will design, fabricate and test in-vivo performance of a two dimensional array of this type of electrodes for chronic, long-term (greater than 3 months) multi-site recording. PROPOSED COMMERCIAL APPLICATION: The potential for commercial application of the proposed technology in biomedical industry is immense. Bioactive micro- and mesoporous Si surfaces have the potential to be used in biochip integration, wound repair, drug delivery and reconstructive prosthesis where some material corrosion is actually desirable. For applications which require more surface stability such as in biosensing and biofiltration, macroporous silicon could enable fabrication of a new generation of more advanced and biocompatible devices.

描述（由申请人提供）：该计划的总体目标是 使用纳米结构多孔硅涂层增强生物相容性 基于陶瓷的多位点神经记录电极（CBMSE）阵列。与德雷克塞尔大学的 K. Moxon 合作，我们已经制造了 CBMSE 阵列可长期记录多个单个神经元活动长达 至三周。然而，为了使用这些电极进行长期研究 或者作为神经假体装置的神经接口组件，录音将 必须维持数月甚至数年。我们建议使用多孔 硅纳米结构作为支架系统，附着在 CBMSE 阵列上。我们 预计多孔硅支架系统将a）携带神经营养因子 电极的插入区域，以尽量减少神经损伤，b) 促进 电极/组织界面处的神经生长，以更好地接触 CBMSE 阵列上带有神经元的记录位点。论证可行性 为了实现第一阶段的这一目标，Spire 与德雷克塞尔大学合作，将 制造单元素多孔硅涂层 CBMSE 基电极 植入一组实验室老鼠体内，对神经组织的影响将 在不同的时间间隔进行评估。将评估神经组织 使用组织学方法寻找植入部位附近的神经损伤 并研究神经元在多孔硅涂层电极中的生长。博士。 麻省总医院医学博士M. Frosch将协助翻译 这些组织学发现。第二阶段，优化流程后 生产混合多孔硅-CBMSE电极的参数，我们将 设计、制造和测试二维阵列的体内性能 此类电极适用于慢性、长期（大于3个月） 多站点录制。 拟议的商业应用：所提出的技术在生物医学行业的商业应用潜力是巨大的。 生物活性微孔和介孔硅表面有潜力用于生物芯片集成、伤口修复、药物输送和重建假体，这些领域实际上需要一些材料腐蚀。 对于需要更高表面稳定性的应用，例如生物传感和生物过滤，大孔硅可以制造新一代更先进和生物相容性的设备。