Nanophase Ceramics as Bone Implant Coatings

纳米相陶瓷作为骨植入涂层

• 批准号: 6793961
• 负责人: NADER M KALKHORAN
• 金额: $ 19.94万
• 依托单位: SPIRE CORPORATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6793961
• 关键词: X ray crystallography; atomic force microscopy; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biotechnology; bone development; bone prosthesis; dental implants; hydroxyapatites; laboratory rat; membrane fusion; nanotechnology; orthopedics; scanning electron microscopy; surface coating; yttrium

DESCRIPTION (provided by applicant): The overall objective of the proposed study is to create a new family of "smart" orthopedic and dental implant coating materials that enhance new bone formation over existing implants. "Smart" coating materials are necessary to selectively increase bone cell function while, at the same time, inhibit functions of competitive cells that lead to soft, instead of bony, tissue formation. Such osseointegration provides mechanical stability to an implant in situ, minimizes motion-induced damage to surrounding tissues, and is imperative for the clinical success of bone implants. In this manner, the health relatedness of the proposed project is to increase bonding between an implant and juxtaposed bone so that a patient who has received joint or dental replacement surgery may quickly return to a normal active lifestyle. Furthermore, the present proposal aims to increase the service-life of an orthopedic material by creating materials that form a strong, long lasting, bond with juxtaposed bone. The material proposed in the present study as a more effective orthopedic implant coating is: nanophase hydroxyapatite doped with yttrium. Nanophase ceramics are intriguing new material formulations since they possess grain sizes less than 100 nm in diameter. For this reason, nanophase ceramics simulate the grain size and topography of bone. Hydroxyapatite doped with yttrium coatings may increase initial absorption of calcium from serum leading to select protein adsorption to enhance bone cell function. This is speculated since yttrium has a high affinity for calcium. When not used as an implant coating, previous studies have determined that nanophase hydroxyapatite doped with yttrium increases bone cell function over existing hydroxyapatite formulations. The present study will build upon these results by using a novel technique to coat a currently utilized bone prosthetic material (titanium) with nanophase hydroxyapatite doped with yttrium. For Phase I studies, the ability of the titanium coated nanophase hydroxyapatite doped with yttrium to promote new bone synthesis and limit competitive cell function will be determined using in vitro cellular models. Specifically, osteoblast (bone-forming cells) and fibroblast (cells that have been associated with competitive soft tissue formation) function will be determined on the proposed coated materials. The specific aims of this proposal are therefore to combine previously designed materials that enhance new bone formation with a novel technique that will transform these bioactive materials into a practical bone prosthetic coating. Undoubtedly, design criteria used in the proposed study to investigate new coating techniques coupled with a new coating material could have great impact in the development of the "next-generation" of orthopedic implants with an improved ability to bind to juxtaposed bone.

描述（由申请人提供）：拟议研究的总体目标是创建一个新的“智能”骨科和牙科种植体涂层材料家族，以增强现有种植体的新骨形成。“智能”涂层材料对于选择性地增加骨细胞功能是必要的，同时，抑制竞争细胞的功能，导致柔软的，而不是骨，组织的形成。这种骨整合为原位种植体提供了机械稳定性，最大限度地减少了运动引起的对周围组织的损伤，对骨种植体的临床成功至关重要。通过这种方式，拟议项目的健康关系是增加种植体和并列骨骼之间的结合，以便接受关节或牙齿置换手术的患者可以迅速恢复正常的积极生活方式。此外，目前的提案旨在通过创造与并列骨形成牢固、持久的结合的材料来增加骨科材料的使用寿命。本研究提出的更有效的骨科种植体涂层材料是：掺杂钇的纳米羟基磷灰石。纳米陶瓷是一种引人注目的新材料配方，因为它们的粒径小于100纳米。因此，纳米相陶瓷可以模拟骨的晶粒尺寸和形貌。羟基磷灰石掺杂钇涂层可能增加钙从血清的初始吸收，导致选择蛋白质吸附，以增强骨细胞的功能。这是推测，因为钇对钙有很高的亲和力。当不用作植入涂层时，先前的研究已经确定掺杂钇的纳米羟基磷灰石比现有的羟基磷灰石配方更能提高骨细胞的功能。本研究将以这些结果为基础，采用一种新技术，在目前使用的骨假体材料（钛）上涂覆掺杂钇的纳米羟基磷灰石。在I期研究中，将使用体外细胞模型来确定钛包覆的掺杂钇的纳米羟基磷灰石促进新骨合成和限制竞争性细胞功能的能力。具体来说，成骨细胞（骨形成细胞）和成纤维细胞（与竞争性软组织形成相关的细胞）的功能将在拟议的涂层材料上确定。因此，该提案的具体目标是将先前设计的增强新骨形成的材料与一种新技术结合起来，将这些生物活性材料转化为实用的骨假体涂层。毫无疑问，在这项研究中使用的设计标准，以研究新的涂层技术和新的涂层材料，可能会对“下一代”骨科植入物的发展产生重大影响，这些植入物与并列骨的结合能力有所提高。

项目成果

Nanocrystalline hydroxyapatite/titania coatings on titanium improves osteoblast adhesion.

• DOI: 10.1002/jbm.a.31469
• 发表时间: 2008
• 期刊: Journal of biomedical materials research. Part A
• 作者: Michiko Sato;A. Aslani;Marisa A. Sambito;N. Kalkhoran;E. Slamovich;T. Webster

Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium.

• DOI: 10.1016/j.biomaterials.2005.10.041
• 发表时间: 2006-04
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Michiko Sato;Marisa A. Sambito;A. Aslani;N. Kalkhoran;E. Slamovich;T. Webster