Bent Laue Analyzer for X-ray Fluorescence Spectroscopy

用于 X 射线荧光光谱分析的 Bent Laue 分析仪

• 批准号: 6485664
• 负责人: CAHIT KARANFIL
• 金额: $ 12.5万
• 依托单位: QUERCUS TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6485664
• 关键词: X ray spectrometry; bioengineering /biomedical engineering; biomedical device power system; biomedical equipment development; cost effectiveness; crystallization; electrical potential; energy source; evaluation /testing; mathematics; method development; radiofluorescent probe

We have invented a novel class of bent laue x-ray analyzer systems that offer unique capabilities for x-ray absorption spectroscopic and x-ray microprobe studies of dilute metalloproteins, biomaterials and bioengineering research, and environmental sciences. This detector concept has been received with great interest in the XAFS community and it is clear there would be significant demand if commercialized in an appropriate manner. Performance of this detector systems is expected to be exceptional in regard to energy resolution, maximum count rate, and time response, and the cost to the end user could be very reasonable. The goal of this proposal is to determine optimal designs, and to constructs and test this new class of detectors in a lower energy range than previously attempted. If successful, the devices will be made available commercially at reasonable cost to experimenters and synchrotron facilities. Although devices of this type have been successfully tested at high energies (20 KeV and above), we intend to develop optimal designs in the range from 4 KeV to 15 KeV, and also to explore alternative methods of fabrication and shaping the extremely thin crystals that are needed at low energies. Methods of maximizing throughput by two- dimensional bending and construction of multi-element arrays also will e investigated. PROPOSED COMMERCIAL APPLICATIONS: This class of devices has substantial potential commercial impact serving the x-ray spectroscopy community. Near-term revenue estimates are in the $5M range. Secondary impact will be even more important because this represents an enabling technology for biomedical sciences, bioengineering, materials research, chemistry, physics, and environmental sciences.

我们发明了一种新型的弯曲法x射线分析仪系统，为稀释金属蛋白，生物材料和生物工程研究以及环境科学的x射线吸收光谱和x射线微探针研究提供了独特的功能。XAFS社区对这个检测器概念非常感兴趣，很明显，如果以适当的方式商业化，将会有很大的需求。在能量分辨率、最大计数率和时间响应方面，该探测器系统的性能预计将是卓越的，并且最终用户的成本可能非常合理。该提案的目标是确定最佳设计，并在比以前尝试的更低的能量范围内构建和测试这种新型探测器。如果成功，该装置将以合理的成本提供给实验人员和同步加速器设施。虽然这种类型的设备已经在高能量（20 KeV及以上）下成功测试，但我们打算在4 KeV至15 KeV范围内开发最佳设计，并探索制造和塑造低能所需的极薄晶体的替代方法。通过二维弯曲和多单元阵列的构建来最大化吞吐量的方法也将被研究。建议的商业应用：这类设备具有巨大的潜在商业影响，服务于x射线光谱学社区。近期收益预计在500万美元左右。二次影响将更加重要，因为它代表了生物医学科学、生物工程、材料研究、化学、物理和环境科学的一种使能技术。