Characterizing P2Y: Receptor Activity as a Therapeutic Target in Respiratory Infection leading to Systematic Inflammation and Sepsis

P2Y 的特征：受体活性作为导致系统性炎症和脓毒症的呼吸道感染的治疗靶点

• 批准号: 1937668
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1937668
• 关键词: Characterizing; P2Y; Receptor; Activity; Therapeutic

We have identified that the platelet P2Y receptor is necessary for important inflammatory processes that occur in both non-allergic and allergic pulmonary inflammation, a phenomenon that is very different to P2Y mediated platelet activity leading to aggregation. The aim of this project is to characterize P2Y signalling and activation of platelets and profile the suitability of P2Y as a therapeutic target during inflammation and infection, using murine models, in vitro functional assays and access to blood samples of critically patients with inflammation arising from sepsis and Adult Respiratory Distress Syndrome (ARDS).

我们已经确定，血小板P2Y受体是在非过敏性和过敏性肺部炎症中发生的重要炎症过程所必需的，这是一种与P2Y介导的血小板活性导致聚集非常不同的现象。该项目的目的是表征P2Y信号传导和血小板活化，并使用小鼠模型，体外功能测定和获得脓毒症和成人呼吸窘迫综合征（ARDS）引起炎症的危重患者的血液样本，描述P2Y作为炎症和感染期间治疗靶点的适用性。