PREVENTION OF RECURRENCE OF MAJOR DEPRESSIVE BEHAVIOR

预防重度抑郁行为复发

• 批准号: 6598491
• 负责人: W. EDWARD CRAIGHEAD
• 金额: $ 2.51万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6598491
• 关键词: behavioral /social science research tag; clinical research; cognitive behavior therapy; group therapy; handbook; human subject; longitudinal human study; major depression; mental disorder diagnosis; mental disorder prevention; relapse /recurrence; therapy compliance; university student

Nearly one-quarter of young adults will experience a Major Depressive Disorder (MDD) by the age of 18, and about one-half of these individuals will suffer from a recurrence during the two years following the first episode. Because of the debilitating effects of MDD on the individual and society, including the overuse of medical services by these citizens, this is a major national health problem. We will begin by writing an intervention manual for an integrated interpersonal, cognitive, and behavioral program designed to prevent the recurrence of MDD among entering college freshmen. The program consists of 12 weekly group sessions conducted over both semesters of the freshmen year. We will also develop reliable adherence and competence measures to evaluate the fidelity and quality of the implementation of the preventive program. In the proposed pilot study we will randomly assign 96 college freshmen who have had a previous MDD but are not currently depressed to either the recurrence prevention program or to treatment as usual; all these students will participate in standard assessment, including diagnostic interviews, at baseline, 6-, 12-, and 18-months. During the first year we will write the manual, develop the adherence and competence measures, randomly assign 24 participants each to one of the two conditions, and re-assess them at 6 months. During the second year, we will randomly assign 24 more participants to each condition, re-assess them at 6 months, and follow-up the first year participants at 12- and 18-months. During the third year we will follow-up the second year participants at 12- and 18-months, analyze and report the data, and revise the prevention manual. Results from the proposed study should allow us to: develop a revised prevention manual which will be employed in a subsequent large randomized controlled trial studying the prevention of recurrence of MDD in college settings; estimate the effect and sample sizes for the subsequent prevention study; and, begin to develop a manual for prevention of recurrence of MDD among young adults in community mental health centers and HMOs.

近四分之一的年轻人在18岁时会经历重度抑郁症（MDD），其中约一半的人会在第一次发作后的两年内复发。 由于MDD对个人和社会的破坏性影响，包括这些公民过度使用医疗服务，这是一个重大的国家健康问题。 我们将开始写一本干预手册，为一个综合的人际，认知和行为计划，旨在防止抑郁症的复发进入大学新生。 该计划包括12个每周小组会议进行了两个学期的大一。 我们还将制定可靠的坚持和能力措施，以评估预防计划实施的忠诚度和质量。在拟议的试点研究中，我们将随机分配96名大学新生，他们以前患有MDD，但目前没有抑郁症，要么复发预防计划，要么照常治疗;所有这些学生都将参加标准评估，包括诊断访谈，在基线，6个月，12个月和18个月。 在第一年，我们将编写手册，制定依从性和能力指标，随机分配24名参与者，每一个到两个条件之一，并在6个月后重新评估他们。 在第二年，我们将为每种情况随机分配24名参与者，在6个月时重新评估他们，并在12个月和18个月时对第一年的参与者进行随访。 在第三年，我们将在12个月和18个月时对第二年的参与者进行随访，分析和报告数据，并修订预防手册。从拟议的研究结果应该允许我们：制定一个修订的预防手册，这将在随后的大型随机对照试验中使用，研究在大学环境中预防MDD复发;估计后续预防研究的效果和样本量;和，开始制定一个手册，预防社区精神卫生中心和HMO的年轻人中的MDD复发。

项目成果

Interpersonal competence across domains: relevance to personality pathology.

跨领域的人际交往能力：与人格病理学的相关性。

• DOI: 10.1521/pedi.2011.25.1.16
• 发表时间: 2011
• 期刊: Journal of personality disorders
• 影响因子: 2.3
• 作者: Muralidharan,Anjana;Sheets,ErinS;Madsen,Joshua;Craighead,LindaW;Craighead,WEdward
• 通讯作者: Craighead,WEdward

Prevention of recurrence of major depression among emerging adults by a group cognitive-behavioral/interpersonal intervention.

• DOI: 10.1016/j.jad.2012.08.036
• 发表时间: 2013-05
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Sheets, Erin S.;Craighead, Linda Wilcoxon;Brosse, Alisha L.;Hauser, Monika;Madsen, Joshua W.;Craighead, W. Edward
• 通讯作者: Craighead, W. Edward

Personality pathology factors predict recurrent major depressive disorder in emerging adults.

人格病理学因素可预测新兴成年人复发性重度抑郁症。

• DOI: 10.1002/jclp.22028
• 发表时间: 2014
• 期刊: Journal of clinical psychology
• 影响因子: 3
• 作者: Sheets,ErinS;Duncan,LaramieE;Bjornsson,AndriS;Craighead,LindaW;Craighead,WEdward
• 通讯作者: Craighead,WEdward

Comparing chronic interpersonal and noninterpersonal stress domains as predictors of depression recurrence in emerging adults.

比较慢性人际和非人际压力领域作为新兴成年人抑郁症复发的预测因素。

• DOI: 10.1016/j.brat.2014.09.001
• 发表时间: 2014
• 期刊: Behaviour research and therapy
• 影响因子: 4.1
• 作者: Sheets,ErinS;Craighead,WEdward
• 通讯作者: Craighead,WEdward