Identifying target regions for Neurofeedback treatment of auditory hallucinations using EEG of experimentally induced and pathological hallucinations

精神分裂症患者的听觉言语幻觉(AVH)模型认为，它们是内部语言错误归因于外部来源。几项功能磁共振研究表明，AVH期间辅助运动区(SMA)的活动减少。然而，功能磁共振成像的时间分辨率有限，而在功能磁共振成像病例对照研究中，脑症状相关性存在潜在的混淆。这项研究将改进的脑电时间分辨率与症状建模方法和患者研究相结合，以描绘SMA与AVH的关系。研究(I)：对有催眠反应的个体进行AVH前、中、后的脑电测量，对AVH提出建议。我们验证了在AVH期间额颞部导联的脑电指数选择性降低的假设。我们认为这表明SMA的低活性和与语言生成区的功能耦合是AVH的直接脑机制。研究(II)：我们将这一设计扩展到慢性动静脉高压患者，检验相同的假设。

Models of auditory verbal hallucinations (AVH) in schizophrenia view them as inner speech misattributed to an external source. Several fMRI studies implicate reduced activity of supplementary motor area (SMA) during AVH. However, fMRI has limited temporal resolution, while brain-symptom correlations in fMRI case-control studies have potential confounds. This study combines the improved temporal resolution of EEG with a symptom modelling approach and patient studies to delineate the relationship of SMA to AVH. Study (i): suggestions for AVH in hypnotically responsive individuals with EEG measurement before, during, and after AVH. We test the hypothesis that EEG indices are selectively reduced in frontotemporal leads during AVH. We interpret this as indicating lower activity of SMA and functional coupling with language generation regions as the proximate brain mechanism of AVH. Study (ii): we extend this design to patients with chronic AVH, testing the same hypothesis.