Identifying target regions for Neurofeedback treatment of auditory hallucinations using EEG of experimentally induced and pathological hallucinations

利用实验诱发幻听和病理幻觉的脑电图确定神经反馈治疗幻听的目标区域

• 批准号: 1938255
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1938255
• 关键词: Identifying; target; regions; Neurofeedback; treatment

Models of auditory verbal hallucinations (AVH) in schizophrenia view them as inner speech misattributed to an external source. Several fMRI studies implicate reduced activity of supplementary motor area (SMA) during AVH. However, fMRI has limited temporal resolution, while brain-symptom correlations in fMRI case-control studies have potential confounds. This study combines the improved temporal resolution of EEG with a symptom modelling approach and patient studies to delineate the relationship of SMA to AVH. Study (i): suggestions for AVH in hypnotically responsive individuals with EEG measurement before, during, and after AVH. We test the hypothesis that EEG indices are selectively reduced in frontotemporal leads during AVH. We interpret this as indicating lower activity of SMA and functional coupling with language generation regions as the proximate brain mechanism of AVH. Study (ii): we extend this design to patients with chronic AVH, testing the same hypothesis.

精神分裂症中的听觉言语幻觉（AVH）模型将其视为错误归因于外部来源的内部言语。一些fMRI研究暗示AVH时补充运动区（SMA）的活动减少。然而，fMRI的时间分辨率有限，而fMRI病例对照研究中的脑症状相关性存在潜在的混淆。本研究结合改善的EEG时间分辨率与症状建模方法和患者研究来描述SMA与AVH的关系。研究（i）：在AVH之前、期间和之后通过EEG测量对催眠反应个体的AVH提出建议。我们测试的假设，脑电指标选择性减少额颞叶导联AVH。我们认为这表明SMA活性降低，与语言产生区域的功能耦合是AVH的最接近的脑机制。研究（ii）：我们将此设计扩展到慢性AVH患者，检验相同的假设。