RECYCLE OF 3HE FOR HIGH RESOLUTION LUNG IMAGING

3HE 的回收用于高分辨率肺部成像

• 批准号: 6537691
• 负责人: MICHAEL G IZENSON
• 金额: $ 36.13万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2003-12-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6537691
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; contrast media; cryoscience; helium; human subject; lung imaging /visualization /scanning; magnetic resonance imaging; physical separation; respiratory gas; stable isotope; technology /technique development

DESCRIPTION (Applicant's abstract verbatim): Noble gas isotopes that can be nuclear spin-polarized are very attractive imaging agents because of their high detection sensitivity for nuclear magnetic resonance. In particular, spin-polarized 3He enables fast, gas-space imaging of the lungs and airways for clinical diagnosis and physiological studies. Unfortunately, the limited availability of 3He severely limits the number of high-resolution lung imaging studies that can be performed. We propose to develop a system to recover and recycle the rare helium isotope so that high-resolution lung imaging can become common and inexpensive. The innovation is a cryogenic gas separation system that extracts and purifies the 3He from a patient's exhalation stream and saves it for re-polarization and reuse in other patients. In Phase I we proved the feasibility of the 3He recovery system by (1) performing a proof-of-concept test that demonstrates the feasibility of efficiently separating, purifying, and sterilizing the 3He from exhalation gases, and (2) producing a conceptual design of a complete system to recover and recycle 3He. In Phase II we will build and demonstrate a complete recovery and recycling system. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（申请人摘要逐字逐句）：稀有气体同位素可以