Field Cooling System for Therpeutic Hypothermia

用于低温治疗的现场冷却系统

• 批准号: 6643278
• 负责人: MICHAEL G IZENSON
• 金额: $ 13.7万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643278
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; cold temperature; evaporation; heart arrest; induced hypothermia; swine

DESCRIPTION (provided by applicant): Recent clinical research indicates a significant benefit to neurological outcomes associated with mild therapeutic hypothermia after cardiac arrest. Presumably, the sooner such treatment can begin, the greater the potential benefit and the greater the number of patients who might benefit. However, there is presently no practical way for paramedics or first responders to provide cooling for hypothermia in the field. Mechanical cooling systems are power hungry, heavy, and expensive. Ice and chemical ice packs have many obvious practical problems with field storage, transport, patient treatment when wet, and lack of temperature control. In the proposed effort, a novel spacesuit cooling technology will be adapted to provide a reliable, lightweight, inexpensive, very low power, easily controlled cooling source that will enable mild therapeutic hypothermia treatment to begin early in the field immediately after cardiac resuscitation. The proposed cooling system is based on regenerable heat absorption. During Phase I, a proof-of-concept cooler with a capacity of approximately 200 W-hr of refrigeration and a cooling pad will be fabricated and demonstrated in bench top and animal experiments. During Phase I, a complete prototype will be developed and demonstrated.

描述（由申请人提供）： 最近的临床研究表明，心脏骤停后轻度低温治疗对神经系统结局有显著益处。据推测，这种治疗开始越早，潜在的益处就越大，受益的患者人数也就越多。然而，目前还没有实用的方法让护理人员或急救人员在现场为体温过低提供冷却。机械冷却系统耗电、笨重且昂贵。冰和化学冰袋在野外储存、运输、潮湿时的病人治疗以及缺乏温度控制方面有许多明显的实际问题。在拟议的努力中，一种新的宇航服冷却技术将被改造，以提供一种可靠、轻便、廉价、功率极低、易于控制的冷却源，使轻度治疗性低温治疗能够在心脏复苏后立即开始。所提出的冷却系统是基于可再生的热吸收。在第一阶段，将制造一个制冷能力约为200瓦时的概念验证冷却器和一个冷却垫，并在实验台和动物实验中进行演示。在第一阶段，将开发和演示一个完整的原型。