Neuroprotection for Stroke Victims Using Xenon

使用氙气对中风患者进行神经保护

• 批准号: 6834452
• 负责人: MICHAEL G IZENSON
• 金额: $ 13.46万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834452
• 关键词: biomedical equipment development; charcoal; disease /disorder model; drug administration rate /duration; drug delivery systems; drug screening /evaluation; emergency care; environmental contamination; health care cost /financing; laboratory rat; miniature biomedical equipment; neural degeneration; neuroprotectants; nonhuman therapy evaluation; patient safety /medical error; stroke therapy; therapy design /development; xenon

DESCRIPTION (provided by applicant): The overall, long-term objective is to improve the outcomes for hundreds of thousands of stroke victims each year. The approach is to (1) demonstrate the effectiveness of xenon as a neuroprotectant and determine the optimal treatment protocol, and (2) develop a xenon delivery apparatus that can be used by emergency medical personnel to quickly and economically provide neuroprotection to stroke victims. The specific aims of the project are enhanced neuroprotection, very low environmental impact, a practical and easy-to-use system, and low overall cost. Phase I will prove the feasibility of this approach with (a) animal model experiments at The University of Massachusetts Medical School (UMass) that will further show the potential effectiveness of xenon as a neuroprotectant and explore optimal treatment protocols, and (b) testing and design analysis at Cream to show the feasibility of a compact, lightweight, and economical system for neuroprotection using xenon.

描述（由申请人提供）：总体而言，长期目标是改善每年数十万中风患者的预后。该方法旨在(1)证明氙气作为神经保护剂的有效性，并确定最佳治疗方案；(2)开发一种氙气输送装置，供急救医务人员使用，快速、经济地为中风患者提供神经保护。该项目的具体目标是增强神经保护，非常低的环境影响，一个实用和易于使用的系统，以及低