Safe, Low-Cost Anesthesia Using Recycled Xenon Gas

使用回收氙气进行安全、低成本的麻醉

• 批准号: 6403985
• 负责人: MICHAEL G IZENSON
• 金额: $ 9.99万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6403985
• 关键词: biomedical equipment development; chemical property; chemical structure; cost effectiveness; gas; inhalation anesthesia; physical separation; technology /technique development; xenon

DESCRIPTION (Verbatim from the Applicant's Abstract): Xenon gas is a very attractive anesthetic agent because of its minimal effects on the cardiovascular system and rapid induction and emergence. However, xenon is used only rarely because of its high cost compared to common inhaled anesthetic agents. Even if it were not so costly, the limited supply of xenon would greatly restrict its use as an anesthetic. The long-term objective of this application is to make xenon anesthesia available for widespread use at low cost. The specific aim is to develop processes and devices to recycle xenon gas by collecting waste gases from anesthesia procedures, then separating and purifying the xenon for re-use. Phase I proves feasibility by (1) demonstrating the key process steps required to separate xenon from typical anesthetic waste gas, (2) producing conceptual designs for all devices needed to accomplish xenon recovery, and (3) showing by analysis that the cost of recycled xenon will be competitive with common inhaled anesthetic agents. PROPOSED COMMERCIAL APPLICATION: Low-cost xenon anesthetic gas will be attractive for two broad applications: (1) xenon gas will be the anesthetic agent of choice for a large fraction of the millions of surgical procedures that are performed each year in the United States on patients with cardiovascular conditions; and (2) because of fewer complications and rapid induction and emergence, xenon anesthesia can reduce patient time in the hospital, with large benefits to health care costs. The proposed research will lead directly to processes and devices that will provide a low-cost source of xenon for these widespread applications.

描述（逐字摘自申请人摘要）：氙气是一种非常 有吸引力的麻醉剂，因为它对身体的影响最小 心血管系统快速诱导和苏醒。然而，使用的是氙气 由于与普通吸入麻醉剂相比成本较高，因此很少使用 代理。即使成本不是那么高，氙气的供应有限 极大地限制了其作为麻醉剂的用途。本次活动的长远目标 该应用的目的是使氙气麻醉能够在低温度下广泛使用 成本。具体目标是开发回收氙气的工艺和设备 通过收集麻醉过程中产生的废气，然后分离和 纯化氙以供重复使用。第一阶段通过 (1) 论证证明可行性 从典型麻醉废物中分离氙所需的关键工艺步骤 气体，(2) 为完成任务所需的所有设备进行概念设计 氙气回收，（3）分析表明，回收氙气的成本 将与普通吸入麻醉剂竞争。 拟议的商业应用： 低成本的氙气麻醉气体将在两个广泛的应用中具有吸引力：(1) 氙气 将成为数百万例外科手术中很大一部分的首选麻醉剂 每年在美国对患有心血管疾病的患者进行的实验； (2) 氙气麻醉由于并发症少、诱导和苏醒速度快 可以减少患者在医院的时间，对医疗保健成本有很大好处。 拟议的 研究将直接导致提供低成本来源的工艺和设备 氙气用于这些广泛的应用。