CORE--ORGANIC PREPARATIONS AND ANALYTICAL LABORATORY SERVICES

核心——有机制剂和分析实验室服务

• 批准号: 6444597
• 负责人: KAMAL N TIWARI
• 金额: $ 22.84万
• 依托单位: SOUTHERN RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6444597
• 关键词: analytical chemistry; antineoplastics; biomedical facility; chemical synthesis; drug design /synthesis /production; high throughput technology; nucleoside analog; nucleoside triphosphate; organic chemicals; prodrugs

APPLICANT'S DESCRIPTION: (provided by Applicant) The overall goals of this core are twofold. The main goal is to provide a mechanism for the larger scale synthesis or resynthesis of intermediates and final products to be used by all of the projects in the grant. An additional goal is to provide a mechanism 1) for the purchase of disposable items for our Analytical Services Group to use for all of the synthetic organic projects; and 2) for defraying the appropriate percentage of maintenance time required for keeping our instruments in top operating condition. As part of this first goal, we will also synthesize needed triphosphates of nucleosides for biological experiments. In the beginning, we need to synthesize the triphosphate of two nucleosides, 4(-thio-ara-C and 2-chloro-2(-deoxy-2(-fluoroadenosine, for mechanism of action studies in Project 16. The triphosphates of other nucleosides will be synthesized as needed.

申请人的描述：（申请人提供） 核心是双重的。 主要目标是为更大的机制提供机制 中间体和最终产品的比例合成或重新合成 赠款中的所有项目。 另一个目标是提供 机制1）为我们的分析服务购买一次性物品 用于所有合成有机项目的小组； 2）支票 保持我们的维护时间的适当百分比 仪器处于最佳操作条件。 作为第一个目标的一部分，我们将 还合成生物学的核苷所需的三磷酸盐 实验。 一开始，我们需要合成两个的三磷酸 核苷，4（-thio-ara-c和2-氯-2（-Deoxy-2）（-fluoroadenosine，用于 项目16中的作用研究机理。 核苷将根据需要合成。